ChemicalBook > CAS DataBase List > 2-Amino-5-methyl-1,3,4-thiadiazole

2-Amino-5-methyl-1,3,4-thiadiazole

Product Name
2-Amino-5-methyl-1,3,4-thiadiazole
CAS No.
108-33-8
Chemical Name
2-Amino-5-methyl-1,3,4-thiadiazole
Synonyms
5-METHYL-1,3,4-THIADIAZOL-2-AMINE;5-methyl-1,3,4-thiadiazole-2-amine;usafcy-3;TOSLAB 27625;AKOS BBS-00007966;VITAS-BB TBB000116;TIMTEC-BB SBB000045;2-AMINO-5-METHYLTHIADIAZOLE;4-thiadiazol-2-amine,5-methyl-3;4-thiadiazole,2-amino-5-methyl-3
CBNumber
CB1676271
Molecular Formula
C3H5N3S
Formula Weight
115.16
MOL File
108-33-8.mol
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2-Amino-5-methyl-1,3,4-thiadiazole Property

Melting point:
223-228 °C
Boiling point:
261.2±23.0 °C(Predicted)
Density 
1.287 (estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
solid
pka
3.84±0.10(Predicted)
color 
Off-White
InChI
InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6)
InChIKey
HMPUHXCGUHDVBI-UHFFFAOYSA-N
SMILES
S1C(C)=NN=C1N
CAS DataBase Reference
108-33-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-37/39-26
WGK Germany 
3
RTECS 
XI3500000
Hazard Note 
Irritant
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
686166
Product name
2-Amino-5-methyl-1,3,4-thiadiazole
Purity
97%
Packaging
5g
Price
$44.31
Updated
2025/07/31
TCI Chemical
Product number
A0874
Product name
2-Amino-5-methyl-1,3,4-thiadiazole
Purity
>98.0%(T)
Packaging
5g
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
A0874
Product name
2-Amino-5-methyl-1,3,4-thiadiazole
Purity
>98.0%(T)
Packaging
25g
Price
$169
Updated
2025/07/31
TRC
Product number
A617080
Product name
2-Amino-5-methyl-1,3,4-thiadiazole
Packaging
50g
Price
$325
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA34351
Product name
2-Amino-5-methyl-1,3,4-thiadiazole
Packaging
250g
Price
$500
Updated
2021/12/16
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2-Amino-5-methyl-1,3,4-thiadiazole Chemical Properties,Usage,Production

Chemical Properties

White to light beige crystalline powder

Uses

2-Amino-5-methyl-1,3,4-thiadiazole was used as a reagent in the synthesis of substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones which diplayed good cytotoxic activities. Also used in the design of new phenothiazine-thiadiazole hybrids for development of antitubercular agents.

Definition

ChEBI: 5-Methyl-1,3,4-thiadiazol-2-amine is a member of thiadiazoles.

Synthesis

64-19-7

79-19-6

108-33-8

1) 0.05 mol of aminothiourea was added to a dry mortar, followed by 0.055 mol of glacial acetic acid, 0.055 mol of silica, and 0.25 mol of phosphorus trichloride, and ground for 10 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:3 by volume as the unfolding agent until the point of raw material aminothiourea disappeared, indicating that the reaction was complete. The crude product was obtained after standing for 30 min.2) The crude product was transferred to a beaker and the pH was adjusted to 8 by adding 5% sodium carbonate solution.The mixture was withdrawn and filtered and the filter cake was dissolved with N,N-dimethylformamide (DMF) to remove silica gel. The filtrate was concentrated under reduced pressure, and after removing the solvent, washed with water and filtered by suction to afford 2-amino-5-methyl-1,3,4-thiadiazole in 95.2% yield.

References

[1] Patent: CN103880776, 2016, B. Location in patent: Paragraph 0024-0026
[2] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 2, p. 637 - 638
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3031 - 3040
[4] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[5] Journal of Chemical Research, 2005, # 5, p. 341 - 343

2-Amino-5-methyl-1,3,4-thiadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-methyl-1,3,4-thiadiazole Suppliers

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View Lastest Price from 2-Amino-5-methyl-1,3,4-thiadiazole manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Henan Fengda Chemical Co., Ltd
Product
2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
Price
US $6.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-24
Career Henan Chemical Co
Product
2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10MT
Release date
2018-12-21

108-33-8, 2-Amino-5-methyl-1,3,4-thiadiazoleRelated Search:

EC 2.6.1.2 Methyl salicylate Tribenuron methyl Methyl acetate Acetaminophen 2-Mercapto-5-methyl-1,3,4-thiadiazole 2,1,3-Benzothiadiazole Kresoxim-methyl N-Ethylmethylamine 2-Amino-1,3,4-thiadiazole Pirimiphos-methyl METSULFURON METHYL N,N-Dimethyl-1,4-phenylenediamine Thiophanate-methyl Tris(hydroxymethyl)aminomethane Methyl 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Methyl bromide

  • TIMTEC-BB SBB000045
  • VITAS-BB TBB000116
  • TOSLAB 27625
  • 4-thiadiazol-2-amine,5-methyl-3
  • 4-thiadiazole,2-amino-5-methyl-3
  • 5-methyl-1,3,4-thiadiazole-2-amine
  • usafcy-3
  • 1,3,4-Thiadiazole, 2-amino-5-methyl.
  • 5-methyl-2-amino-1,3,4-thiadiazole
  • 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 97%
  • 2-AMINO-5-METHYL-1,3,4-THIADIZOLE
  • 5-METHYL-1,3,4-THIADIAZOL-2-AMINE
  • 5-METHYL-[1,3,4]THIADIAZOL-2-YLAMINE
  • AKOS BBS-00007966
  • 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE
  • 2-AMINO-5-METHYLTHIADIAZOLE
  • 2-AMino-5-Methyl-1,3,4-thiadiazole, 97% 5GR
  • 1,3,4-Thiadiazol-2-amine, 5-methyl
  • 2-Amino-5-methyl-1,3,4-thiadiazole,97%
  • 2-Amino-5-methyl-1,3,4-thiadiazole &gt
  • 2-Amino-5-jnethyl-l, 3, 4-thiadi azole
  • 108-33-8
  • 1456-57-9
  • Amines
  • Oxadiazoles & Thiadiazoles
  • API intermediates
  • Oxadiazoles & Thiadiazoles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Thiadiazoles