ChemicalBook > CAS DataBase List > (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE

(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE

Product Name
(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE
CAS No.
3190-70-3
Chemical Name
(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE
Synonyms
Leu-NCA;L-Leu-NCA;L-Leucine NCA;L-Leucine N-Carboxanhydride;L-Leucine N-carboxyanhydride;N-Carboxy-L-leucine anhydride;(4S)-4-Isobutyloxazolidine-2,5-dione;(S)-4-ISOBUTYL-OXAZOLIDINE-2,5-DIONE;(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE;(4S)-4-Isobutyl-1,3-oxazolidine-2,5-dione
CBNumber
CB5427213
Molecular Formula
C7H11NO3
Formula Weight
157.17
MOL File
3190-70-3.mol
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(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Property

Melting point:
76-77°C
Density 
1.124±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
9.38±0.40(Predicted)
Appearance
White to off-white Solid
optical activity
Consistent with structure
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Safety

Safety Statements 
22-24/25
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
C178575
Product name
N-CarboxyleucineAnhydride
Packaging
5g
Price
$860
Updated
2021/12/16
ChemScene
Product number
CS-0031376
Product name
L-LeucineNCA
Purity
≥97.0%
Packaging
1g
Price
$26
Updated
2021/12/16
Activate Scientific
Product number
AS42079
Product name
(S)-4-Isobutyloxazolidine-2,5-dione
Purity
95+% ee
Packaging
1g
Price
$68
Updated
2021/12/16
ChemScene
Product number
CS-0031376
Product name
L-LeucineNCA
Purity
≥97.0%
Packaging
5g
Price
$91
Updated
2021/12/16
ChemScene
Product number
CS-0031376
Product name
L-LeucineNCA
Purity
≥97.0%
Packaging
10g
Price
$152
Updated
2021/12/16
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(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Chemical Properties,Usage,Production

Uses

N-Carboxyleucine Anhydride is a reagent in the synthesis of hybrid polypeptide micelles which are used to load indocyanine green dyes into lab rats for tumor imaging and photothermal effect studies.

Synthesis

75-44-5

61-90-5

3190-70-3

General procedure for the synthesis of (S)-4-isobutyloxazolidine-2,5-dione from phosgene and L-leucine: L-leucine amide (HO-Leu-NH2, 10.0 g, 76.2 mmol) was suspended in 150 mL of anhydrous tetrahydrofuran (THF), and heated to 50 °C. A 20% phosgene solution of toluene (76.0 mL, 152.4 mmol) was slowly added to the amino acid suspension. After about 1 hour, the amino acids were completely dissolved to form a clarified solution. The reaction solution was concentrated on a rotary evaporator, transferred to a beaker, and the product was precipitated by the addition of hexane. The white solid was separated by filtration and dissolved in toluene. The toluene solution was filtered through a bed of diatomaceous earth to remove insoluble impurities. Excess hexane was added to the filtrate to precipitate the product again. N-carboxy-L-leucine anhydride (Leu NCA) was obtained by filtration separation and dried under vacuum. 9.0 g (75% yield) of Leu NCA was finally obtained as a white crystalline solid. Its 1H NMR (d6-DMSO) data were as follows: δ 9.13 (1H), 4.44 (1H), 1.74 (1H), 1.55 (2H), 0.90 (6H) ppm.

References

[1] Advanced Synthesis and Catalysis, 2004, vol. 346, # 9-10, p. 1247 - 1249
[2] Patent: US2008/274173, 2008, A1. Location in patent: Page/Page column 94
[3] Journal of the Chemical Society, 1950, p. 3222,3225
[4] Patent: US2789973, 1950,
[5] Nippon Kagaku Zasshi, 1956, vol. 77, p. 44,46

(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE Suppliers

China 73 Germany 2 India 2 United Kingdom 2 United States 8 Global 87
Aladdin Scientific
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United States
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Synthonix Inc
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SynQuest Laboratories, Inc.
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CarboMer, Inc.
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3B Scientific Corporation
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Alfa Aesar
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View Lastest Price from (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Leu-NCA 3190-70-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-18
Shaanxi Dideu Medichem Co. Ltd
Product
(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE 3190-70-3
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-09
Career Henan Chemical Co
Product
(S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE 3190-70-3
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100 kg
Release date
2020-01-10

3190-70-3, (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONERelated Search:

4-isobutyloxazolidine-2,5-dione (S)-4-Isobutyl-2-Oxazolidinone DL-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE,(R,S)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE NALPHA-9-Fluorenylmethoxycarbonyl-L-leucine N-carboxylic anhydride Z-L-Leucine N-carboxyanhydride N-tert-Butoxycarbonyl-L-leucine N-carboxylic anhydride (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE

  • (S)-(-)-4-ISOBUTYLOXAZOLIDINE-2,5-DIONE
  • (S)-4-ISOBUTYL-OXAZOLIDINE-2,5-DIONE
  • (4S)-4β-(2-Methylpropyl)oxazolidine-2,5-dione
  • (S)-4β-(2-Methylpropyl)-2,5-oxazolidinedione
  • L-Leucine NCA
  • N-Carboxy-L-leucine anhydride
  • L-Leu-NCA
  • L-Leucine N-carboxyanhydride
  • Leu-NCA
  • (4S)-4-Isobutyloxazolidine-2,5-dione
  • (S)-4-Isobutyloxazolidine-2,5-dione(S)-4-Isobutyloxazolidine-2,5-dione
  • L-Leucine N-Carboxanhydride
  • 2,5-Oxazolidinedione, 4-(2-methylpropyl)-, (4S)-
  • 4-(2-methylpropyl)-1,3-oxazolidine-2,5-dione
  • (4S)-4-Isobutyl-1,3-oxazolidine-2,5-dione
  • (4S)-4-(2-methylpropyl)-1,3-oxazolidine-2,5-dione
  • 3190-70-3
  • 190-70-3