ChemicalBook > CAS DataBase List > 3-Fluoro-4-methylphenylboronic acid
3-Fluoro-4-methylphenylboronic acid
- Product Name
- 3-Fluoro-4-methylphenylboronic acid
- CAS No.
- 168267-99-0
- Chemical Name
- 3-Fluoro-4-methylphenylboronic acid
- Synonyms
- AKOS BRN-0218;CHEMBRDG-BB 4003301;3-FLUORO-P-TOLYLBORONIC ACID;3-Fluoro-4-Methylphenylboronic;3-Fluoro-4-methylphenylboronicaci;3-Fluoro-4-methlbenzeneboronicacid;3-Fluoro-4-methbenzene boronic acid;3-FLUORO-4-METHYLPHENYLBORONIC ACID;3-FLUORO-4-METHYLBENZENEBORONIC ACID;B-(3-fluoro-4-Methylphenyl)-Boronicacid
- CBNumber
- CB5429479
- Molecular Formula
- C7H8BFO2
- Formula Weight
- 153.95
- MOL File
- 168267-99-0.mol
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3-Fluoro-4-methylphenylboronic acid Property
- Melting point:
- 232-237 °C (lit.)
- Boiling point:
- 278.7±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 7.76±0.10(Predicted)
- form
- Crystalline Powder
- color
- White
- BRN
- 8544594
- CAS DataBase Reference
- 168267-99-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 26-36/37/39-45-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- F0712
- Product name
- 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0712
- Product name
- 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $91
- Updated
- 2025/07/31
TRC
- Product number
- F596515
- Product name
- 3-Fluoro-4-methylphenylboronic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
Synthonix
- Product number
- F3286
- Product name
- 3-Fluoro-4-methylphenylboronic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC11114
- Product name
- 3-Fluoro-4-methylbenzeneboronicacid
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
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3-Fluoro-4-methylphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
Reactant for:• ;Regioselective Suzuki coupling1,2
Uses
suzuki reaction
Uses
3-Fluoro-4-methylphenylboronic acid is an inhibitor of bacterial quorum sensing in Vibrio harveyi.
Synthesis
39998-81-7
168267-99-0
General procedure for the synthesis of 3-fluoro-4-methylphenylboronic acid from 2-fluoro-4-iodotoluene: In a 50 mL round-bottomed flask (equipped with a side arm, condenser, and stirring bar) triphenylphosphine (0.131 g, 0.5 mmol, 20 mol%), 2-fluoro-4-iodotoluene (0.585 g, 2.5 mmol), and triethylamine (1.78 mL, 12.5 mmol). The reaction system was degassed by alternating vacuum and argon filling three times. Palladium dichloride (0.023 g, 0.13 mmol, 5 mol%) was added under positive argon atmosphere. After stirring for 15 minutes at room temperature, diisopropylaminoborane (5 mL, 1 M THF solution, 5 mmol) was added and the reaction mixture was again degassed by alternating vacuum and argon filling three times. The reaction mixture was heated to reflux and kept at reflux for 12 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and methanol (6 mL, note: this is an exothermic reaction accompanied by hydrogen release) was slowly added. After stirring for 15 minutes, all solvent was removed by distillation under reduced pressure to give a black solid. The solid was dissolved in 3M sodium hydroxide solution (8 mL) and washed with hexane (3 x 10 mL). The aqueous phase was cooled to 0°C (ice bath) and acidified with concentrated hydrochloric acid to pH ≤ 1, at which point 3-fluoro-4-methylphenylboronic acid precipitated as a white solid. The aqueous phase was extracted with ether (3 x 10 mL), the organic phases were combined, dried with magnesium sulfate and filtered. The solvent was removed by distillation under reduced pressure to give a white solid product.
References
[1] Tetrahedron, 2011, vol. 67, # 3, p. 576 - 583
3-Fluoro-4-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-4-methylphenylboronic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-Fluoro-4-methylphenylboronic acid 168267-99-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-Fluoro-4-methylphenylboronic acid 168267-99-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-Fluoro-4-methylphenylboronic acid 168267-99-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
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