1-CBZ-(S)-3-METHYLPIPERAZINE
Uses- Product Name
- 1-CBZ-(S)-3-METHYLPIPERAZINE
- CAS No.
- 612493-87-5
- Chemical Name
- 1-CBZ-(S)-3-METHYLPIPERAZINE
- Synonyms
- (S)-1-Cbz-3-methylpiperazine;(S)-4-CBZ-2-METHYLPIPERAZINE;1-CBZ-(S)-3-METHYLPIPERAZINE;4-CBZ-(S)-2-METHYL PIPERAZINE;(S)-1-Cbz-3-Methyl-piperazine HCl;(S)-4-N-CBZ-2-Methylpiperazine-HCl;(S)-1-CARBOBENZYLOXY-3-METHYLPIPERAZINE;(S)-4-Benzoxycarbonyl-2-methylpiperazine;(S)-1-CARBOBENZYLOXYL-3-METHYLPIPERAZINE;4-N-BENZOXYCARBONYL-2-(S)-METHYLPIPERAZINE
- CBNumber
- CB5431476
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 612493-87-5.mol
1-CBZ-(S)-3-METHYLPIPERAZINE Property
- Boiling point:
- 167°C 1mm
- Density
- 1,1 g/cm3
- refractive index
- 1.5365
- Flash point:
- 178°C
- storage temp.
- 2-8°C(protect from light)
- pka
- 8.50±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- S960050
- Product name
- (S)-Benzyl3-methylpiperazine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0041747
- Product name
- (S)-Benzyl3-methylpiperazine-1-carboxylate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $94
- Updated
- 2021/12/16
- Product number
- CCH0001493
- Product name
- 4-CBZ-(S)-2-METHYL PIPERAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $302.4
- Updated
- 2021/12/16
- Product number
- OR310944
- Product name
- Benzyl(3S)-3-methylpiperazine-1-carboxylate
- Packaging
- 500mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- CS-0041747
- Product name
- (S)-Benzyl3-methylpiperazine-1-carboxylate
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $330
- Updated
- 2021/12/16
1-CBZ-(S)-3-METHYLPIPERAZINE Chemical Properties,Usage,Production
Uses
(S)-benzyl 3-methylpiperazine-1-carboxylate is a useful research chemical.
Synthesis
74879-18-8
501-53-1
612493-87-5
Example 4: To a 1 L four-necked round-bottomed flask equipped with a thermometer, condenser tube and stirring device were added 100.2 g (1.00 mol) of racemic 2-methylpiperazine, 90.0 g (0.600 mol) of D-tartaric acid, 170 g of water and 36.0 g (0.600 mol) of acetic acid. The mixture was heated to 72 °C and aged at this temperature for 2 hours. The amount of solvent was 1.69 times the weight of racemic 2-methylpiperazine. Subsequently, the mixture was cooled to 15 °C over 12 hours and the precipitated crystals were collected by filtration. The resulting crystals were dried under vacuum to give 114.0 g (0.456 mol) of diastereoisomeric salt with an optical purity of 93.25% ee. Based on the amount of S-isomer in racemic 2-methylpiperazine, the yield of S-isomer was 88.0%. Next, 190 g of water and 114.0 g of the above crystals (44.0 g of pure (S)-2-methylpiperazine) were added to a 500 mL flask. After complete dissolution at 80 to 85 °C, the solution was cooled to 15 °C over 5 hours. The precipitated crystals were collected by filtration and dried under vacuum to give 100.5 g of salt with an optical purity of 99.5% ee. Based on the amount of (S)-2-methylpiperazine in the supplied crystals, the yield of the S-isomer was 91.1%. To a 200 mL four-necked round-bottomed flask equipped with a thermometer, condenser tube, and stirring device were added 75 g of water, 25.1 g of (S)-2-methylpiperazine D-tartrate (0.100 mol, 99.5% ee optical purity), and 7.8 g (0.100 mol) of 95% pure calcium hydroxide. The slurry was heated to 70 to 80 °C, stirred for 3 hours and then cooled to room temperature. The undissolved solids were removed by filtration to obtain the mother liquor.GC analysis showed that the mother liquor contained 9.2 g (0.0918 mol) of 2-methylpiperazine in 91.8% yield.HPLC analysis showed that (S)-2-methylpiperazine was optically pure at 99.5% ee.Subsequently, the mother liquor was concentrated to about 50 wt% water content, and azeotropically dehydrated by the addition of 1 -butanol until the system's water content was below 1 wt%. (S)-2-methylpiperazine was isolated by reduced pressure distillation. Using optically pure (S)-2-methylpiperazine (optical purity 99.5% ee) obtained by the above method, the reaction was carried out under the same conditions as in Example 1. The reaction was stirred at 0 to 5°C for 2 hours and then at room temperature for 12 hours. Analysis of the reaction solution showed a yield of 84.6% (based on the amount of 2-methylpiperazine) of 1-benzyloxycarbonyl-3-methylpiperazine and an optical purity of 99.5% ee, with no decrease in optical purity observed.
References
[1] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 17
[2] Patent: WO2004/101546, 2004, A1. Location in patent: Page 24
[3] Patent: WO2006/40192, 2006, A1. Location in patent: Page/Page column 28
1-CBZ-(S)-3-METHYLPIPERAZINE Preparation Products And Raw materials
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View Lastest Price from 1-CBZ-(S)-3-METHYLPIPERAZINE manufacturers
- Product
- 1-CBZ-(S)-3-METHYLPIPERAZINE 612493-87-5
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08