ChemicalBook > CAS DataBase List > D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL

Product Name
D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
CAS No.
80938-69-8
Chemical Name
D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
Synonyms
PDMP;DL-PDMP;DL-threo-PDMP;D,L-THREO-PDMP HCL;DL-THREO-PDMP, HYDROCHLORIDE;(+/-)-THREO-PDMP HYDROCHLORIDE;(+)-threo-1-phenyl-2-decanoylamino-3-*morpholino-;(±)-threo-PDMP hydrochloride, PDMP hydrochloride;(+)-THREO-1-PHENYL-2-DECANOYLAMINO-3-*MO RPHOLINO-1-;1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL, HCL
CBNumber
CB5438950
Molecular Formula
C23H39ClN2O3
Formula Weight
427.03
MOL File
80938-69-8.mol
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D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Property

storage temp. 
-20°C
solubility 
DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:5): 0.05 mg/ml
form 
White solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7340
Product name
(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Packaging
100mg
Price
$464
Updated
2024/03/01
Sigma-Aldrich
Product number
513100
Product name
(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Packaging
50mg
Price
$272
Updated
2024/03/01
Cayman Chemical
Product number
10005276
Product name
DL-threo-PDMP (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
10005276
Product name
DL-threo-PDMP (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$19
Updated
2021/12/16
Cayman Chemical
Product number
10005276
Product name
DL-threo-PDMP (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$199
Updated
2024/03/01
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D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Chemical Properties,Usage,Production

Description

DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo-(1R,2R)-PDMP and L-threo-(1S,2S)-PDMP. DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 μM. It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro. The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo-(1R,2R) enantiomer. The D-threo-PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100. [Matreya, LLC. Catalog No. 1719]

Uses

DL-threo-PDMP can deplete cells and mice of their glucosphinolipids.

Biochem/physiol Actions

Glucosylceramide synthase inhibitor; blocks formation of glucosylceramide from ceramide.

D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL Suppliers

80938-69-8, D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCLRelated Search:


  • N-[2-HYDROXY-1-(4-MORPHOLINYLMETHYL)-2-PHENYLETHYL]-DECANAMIDE, MONOHYDROCHLORIDE
  • (+/-)-THREO-PDMP HYDROCHLORIDE
  • (+/-)-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HYDROCHLORIDE
  • 1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL, HCL
  • DL-PDMP
  • D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
  • D,L-THREO-PDMP HCL
  • DL-THREO-PDMP, HYDROCHLORIDE
  • (+)-threo-1-phenyl-2-decanoylamino-3-*morpholino-
  • (+)-THREO-1-PHENYL-2-DECANOYLAMINO-3-*MO RPHOLINO-1-
  • PDMP HYDROCHLORIDE \ GLUCOSYLCERAMIDE SY NTHASE INHIBITOR
  • (±)-threo-PDMP hydrochloride, PDMP hydrochloride
  • PDMP
  • N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide:hydrochloride
  • (±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol
  • DL-threo-PDMP, Hydrochloride - CAS 80938-69-8 - Calbiochem
  • N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide
  • DL-threo-PDMP
  • (+/-)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
  • 80938-69-8
  • BioChemical
  • Biochemicals and Reagents
  • Glucosylceramide synthase inhibitor
  • Enzymes, Inhibitors, and Substrates
  • D to K
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme