2-Aminopyrimidine-5-boronic Acid Pinacol Ester

Product Name: 2-Aminopyrimidine-5-boronic Acid Pinacol Ester
CAS No.: 402960-38-7
Chemical Name: 2-Aminopyrimidine-5-boronic Acid Pinacol Ester
Synonyms: CAS:402960-38-7;1H-PYRROL-3-OL,1-ETHYL-2-METHYL;5-METHOXYTHIOPHENE-2-BORONIC ACID;2-AMinopyriMidine-5-boronicacidpinacoleste;(2-Aminopyrimidin-5-yl)boronic acid pinaco;2-AMINOPYRIMIDINE-5-BORONIC ACID, PICOL ESTER;2-AMINOPYRIMIDINE-5-BORONIC ACID, PINACOL ESTER;(2-Aminopyrimidin-5-yl)boronic acid pinacol ester;5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine;2-Aminopyrimidine-5-boronic acid pinacol ester - [A1748]
CBNumber: CB5442173
Molecular Formula: C10H16BN3O2
Formula Weight: 221.06
MOL File: 402960-38-7.mol

More

Less

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Property

Melting point:: 209-211°C
Boiling point:: 394.8±34.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
pka: 3.66±0.10(Predicted)
form: solid
color: white to off-white
Water Solubility: Slightly soluble in water. Soluble in chloroform.
InChI: InChI=1S/C10H16BN3O2/c1-9(2)10(3,4)16-11(15-9)7-5-13-8(12)14-6-7/h5-6H,1-4H3,(H2,12,13,14)
InChIKey: BPQVMIDUTRJYSC-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(B2OC(C)(C)C(C)(C)O2)C=N1

More

Less

Safety

Hazard Codes: Xi,Xn,T
Risk Statements: 36/37/38-22-25
Safety Statements: 26-36/37/39-36/39-45
RIDADR: UN 2811 6.1 / PGIII
TSCA: No
HazardClass: IRRITANT
HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BML00109
Product name: 2-Aminopyrimidine-5-boronic acid pinacol ester
Purity: Aldrich
Packaging: 1g
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: A3087
Product name: 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $87
Updated: 2025/07/31

TCI Chemical

Product number: A3087
Product name: 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $256
Updated: 2025/07/31

TRC

Product number: A629055
Product name: 2-Aminopyrimidine-5-boronic acid pinacol ester
Packaging: 500mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 260081
Product name: 2-Aminopyrimidine-5-boronic acid pinacol ester
Packaging: 500mg
Price: $319
Updated: 2021/12/16

More

Less

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Chemical Properties,Usage,Production

Chemical Properties

Light Beige Solid

Uses

2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.

Synthesis

7752-82-1

73183-34-3

402960-38-7

General procedure for the synthesis of 2-aminopyrimidine-5-boronic acid pinacol ester from 2-amino-5-bromopyrimidine and bis(pinacolato)diboron and 5.9 g (60.3 mmol) potassium acetate: 3.5 g (20.1 mmol) 5-bromopyrimidin-2-amine, 5.6 g (22.1 mmol) bis(pinacolato)diboron, and 5.9 g (60.3 mmol) potassium acetate were dissolved in 35 mL of 1,4-dioxane and subsequently 1.41 g (2.01 mmol) of bis(triphenylphosphine)dichloropalladium(II) was added. The reaction mixture was stirred at 110 °C for 4 hours. After completion of the reaction, it was cooled to room temperature, diluted with ethyl acetate and sonicated for 5 minutes. It was filtered through a diatomaceous earth filled filter and washed with ethyl acetate. The filtrate was washed sequentially with distilled water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was dissolved in 100 mL of a solvent mixture of dichloromethane and hexane (1:3, v/v) and stirred at room temperature for 1 hour. It was filtered under reduced pressure and the resulting solid was dried under reduced pressure to give 4 g (yield: 90%) of the target product 2-aminopyrimidine-5-boronic acid pinacol ester.

References

[1] Patent: KR2016/38598, 2016, A. Location in patent: Paragraph 0111; 0112
[2] Organic Process Research and Development, 2016, vol. 20, # 1, p. 95 - 99
[3] Organic Process Research and Development, 2017, vol. 21, # 9, p. 1427 - 1434
[4] Patent: CN106632443, 2017, A. Location in patent: Paragraph 0010-0016
[5] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 89-90

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Suppliers

Americas 1 Canada 1 China 221 Europe 1 France 1 Germany 1 India 2 Japan 2 United Kingdom 6 United States 24 Global 260

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3341
Advantage: 55

Shanghai Youmede Technology Co., LTD

Tel: 18964944463
Email: 56810034@qq.com
Country: China
ProdList: 39
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

More

Less

View Lastest Price from 2-Aminopyrimidine-5-boronic Acid Pinacol Ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Aminopyrimidine-5-boronic Acid Pinacol Ester 402960-38-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-06

Henan Fengda Chemical Co., Ltd

Product: 2-Aminopyrimidine-5-boronic Acid Pinacol Ester 402960-38-7
Price: US $36.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 2-Aminopyrimidine-5-boronic Acid Pinacol Ester 402960-38-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

402960-38-7, 2-Aminopyrimidine-5-boronic Acid Pinacol EsterRelated Search:

2-AMINO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE

2-AMINOPYRIMIDINE-5-BORONIC ACID, PINACOL ESTER

5-METHOXYTHIOPHENE-2-BORONIC ACID

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

2-PyriMidinaMine,5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

2-Aminopyrimidine-5-boronic acid pinacol ester 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine, 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine, 2-aminopyrimidine-5-boronic acid pinacol ester, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-ylamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-ylamine, 2‐aminopyrimidine‐5‐boronic acid, pinacol ester, 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

2-AMINOPYRIMIDINE-5-BORONIC ACID, PICOL ESTER

(2-Aminopyrimidin-5-yl)boronic acid pinacol ester

2-AMinopyriMidine-5-boronicacidpinacoleste

1H-PYRROL-3-OL,1-ETHYL-2-METHYL

2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, 2-(2-Aminopyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(2-Aminopyrimidin-5-yl)boronic acid pinaco

2-(2-Aminopyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Aminopyrimidine-5-boronic Acid Pinacol Ester ISO 9001：2015 REACH

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine, 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine, 2-aminopyrimidine-5-boronic acid pinacol ester, 5-(4,4,5,5-tet

CAS:402960-38-7

2-Aminopyrimidine-5-boronic acid pinacol ester - [A1748]

402960-38-7

40296-38-7

C10H16BN3O2

C10H18BN3O3

Heterocyclic Compounds

Amino

Organoborons

Pyrimidine