ChemicalBook > CAS DataBase List > 4-HYDROXY-6-IODOQUINOLINE

4-HYDROXY-6-IODOQUINOLINE

Product Name
4-HYDROXY-6-IODOQUINOLINE
CAS No.
342617-07-6
Chemical Name
4-HYDROXY-6-IODOQUINOLINE
Synonyms
BUTTPARK 100\01-54;6-Iodo-4-quinolinol;6-IODOQUINOLIN-4-OL;4-Quinolinol, 6-iodo-;6-iodo-1H-quinolin-4-one;6-IODOQUINOLIN-4(1H)-ONE;4-HYDROXY-6-IODOQUINOLINE;4-Hyrdroxy-6-iodoquinoline
CBNumber
CB5447961
Molecular Formula
C9H6INO
Formula Weight
271.05
MOL File
342617-07-6.mol
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4-HYDROXY-6-IODOQUINOLINE Property

Boiling point:
394℃
Density 
1.974
Flash point:
192℃
storage temp. 
2-8°C(protect from light)
pka
3.85±0.40(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
I737140
Product name
6-Iodoquinolin-4-ol
Packaging
100mg
Price
$75
Updated
2021/12/16
Usbiological
Product number
279808
Product name
4-Hyrdroxy-6-iodoquinoline
Packaging
1g
Price
$432
Updated
2021/12/16
Matrix Scientific
Product number
126409
Product name
4-Hydroxy-6-iodoquinoline
Purity
>95%
Packaging
25g
Price
$845
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0055254
Product name
4-HYDROXY-6-IODOQUINOLINE
Purity
95.00%
Packaging
1G
Price
$852.55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0055254
Product name
4-HYDROXY-6-IODOQUINOLINE
Purity
95.00%
Packaging
2.5G
Price
$1227.82
Updated
2021/12/16
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4-HYDROXY-6-IODOQUINOLINE Chemical Properties,Usage,Production

Synthesis

909344-69-0

342617-07-6

The reaction was carried out by batchwise addition of 5-{[(4-iodophenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione (120 g) in diphenyl ether (1.3 L, 8.0 mol) at 240 °C for 1.5 hours. After completion of the reaction, the mixture was cooled to room temperature and poured into 1.5 L of hexane. The resulting suspension was filtered and the filter cake was broken and washed with hexane (2 x 500 mL). The solid was dried under vacuum to afford 6-iodo-4-hydroxyquinoline as a brown solid (80 g, 82% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ11.89 (d, J=4.0 Hz, 1H), 8.36 (d, J=2.3 Hz, 1H), 7.89-7.98 (m, 2H), 7.37 (d, J=8.6 Hz, 1H), 6.07 (dd, J=7.5,1.1 Hz, 1H); mass spectra (m /z) 272.0 (M+H+).

References

[1] Patent: US2012/41024, 2012, A1. Location in patent: Page/Page column 8; 10; 16
[2] Patent: EP2566477, 2015, B1. Location in patent: Paragraph 0157; 0159
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4867 - 4880

4-HYDROXY-6-IODOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-HYDROXY-6-IODOQUINOLINE manufacturers

Career Henan Chemical Co
Product
4-HYDROXY-6-IODOQUINOLINE 342617-07-6
Price
US $1.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-10