4-(tert-ButoxycarbonylaMino)-1-butanol

Product Name: 4-(tert-ButoxycarbonylaMino)-1-butanol
CAS No.: 75178-87-9
Chemical Name: 4-(tert-ButoxycarbonylaMino)-1-butanol
Synonyms: tert-Butyl (4-hydroxybutyl)carbaMate;Boc-4-Abu-ol;4-Boc-Abu-ol;BOC-ABU(4)-OL;BOC-NH-(CH2)4-OH;BOC-4-AMINOBUTANOL;4-BOC AMINO BUTANOL;N-BOC-4-AMINOBUTANOL;4-(BOC-AMINO)-1-BUTANOL;N-Boc-4-Amino-1-butanol
CBNumber: CB5449521
Molecular Formula: C9H19NO3
Formula Weight: 189.25
MOL File: 75178-87-9.mol

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4-(tert-ButoxycarbonylaMino)-1-butanol Property

Melting point:: 29 °C
Boiling point:: 302.7±25.0 °C(Predicted)
Density: 1.02 g/mL at 20 °C(lit.)
refractive index: n20/D 1.456
Flash point:: 29 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.80±0.46(Predicted)
form: Liquid or Low Melting Solid
color: Colorless to yellow
BRN: 3603307
InChI: InChI=1S/C9H19NO3/c1-9(2,3)13-8(12)10-6-4-5-7-11/h11H,4-7H2,1-3H3,(H,10,12)
InChIKey: LIYMTLVBAVHPBU-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCCCO

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Safety

WGK Germany: 3
F: 10-21
HazardClass: IRRITANT
HS Code: 29221985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15302
Product name: 4-(Boc-amino)-1-butanol
Purity: ≥98.0% (GC)
Packaging: 1ml
Price: $106
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15302
Product name: 4-(Boc-amino)-1-butanol
Purity: ≥98.0% (GC)
Packaging: 5ml
Price: $160.5
Updated: 2025/07/31

TCI Chemical

Product number: B2868
Product name: 4-(tert-Butoxycarbonylamino)-1-butanol
Purity: >96.0%(GC)
Packaging: 5g
Price: $193
Updated: 2025/07/31

TCI Chemical

Product number: B2868
Product name: 4-(tert-Butoxycarbonylamino)-1-butanol
Purity: >96.0%(GC)
Packaging: 25g
Price: $654
Updated: 2025/07/31

TRC

Product number: B620825
Product name: 4-(t-Boc-amino)-1-butanol
Packaging: 1g
Price: $65
Updated: 2021/12/16

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4-(tert-ButoxycarbonylaMino)-1-butanol Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Liquid

Uses

Building block for spermidine analogues

Uses

4-(tert-ButoxycarbonylaMino)-1-butanol can be used as an intermediate for the synthesis of polymers used for in vivo delivery polyconjugate systems.

reaction suitability

reagent type: cross-linking reagent

Synthesis

13325-10-5

24424-99-5

75178-87-9

GENERAL STEPS: 4-Amino-1-butanol (0.5 g, 5.61 mmol) was dissolved in acetonitrile (56 mL). The reaction system was cooled to 0 °C, followed by the sequential addition of triethylamine (Et3N, 1.56 mL, 11.22 mmol, 2 equiv) and di-tert-butyl dicarbonate (Boc2O, 1.346 g, 6.17 mmol). The reaction progression was monitored by thin layer chromatography (TLC). After 6.5 h of reaction, the reaction was quenched by the addition of water (20 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 3 × 30 mL) and saturated saline was added to facilitate phase separation. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography (eluent: dichloromethane/methanol, 95:5) to afford 4-(N-tert-butoxycarbonylamino)-1-butanol as a colorless oil (1.06 g, quantitative yield).

References

[1] Organic Letters, 2009, vol. 11, # 9, p. 2019 - 2022
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2536 - 2543
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1151 - 1155
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 191 - 200
[5] Inorganica Chimica Acta, 2016, vol. 452, p. 152 - 158

4-(tert-ButoxycarbonylaMino)-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(tert-ButoxycarbonylaMino)-1-butanol Suppliers

Americas 1 Canada 1 China 115 Europe 1 Germany 1 India 6 Japan 2 Switzerland 1 United Kingdom 2 United States 13 Global 143

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View Lastest Price from 4-(tert-ButoxycarbonylaMino)-1-butanol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-4-Abu-ol 75178-87-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-18

Sichuan Jiaying Lai Technology Co.,LTD

Product: Boc-4-Abu-ol 75178-87-9
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-18

Career Henan Chemical Co

Product: 4-(tert-ButoxycarbonylaMino)-1-butanol 75178-87-9
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

75178-87-9, 4-(tert-ButoxycarbonylaMino)-1-butanolRelated Search:

N-Boc-cadaverine Carbamic acid, (4-amino-2-butynyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, (tetrahydro-4-oxo-2H-pyran-3-yl)-, 1,1-dimethylethyl ester (9CI) tert-butyl N-(4,4-dimethyl-3-oxopentyl)-N-methylcarbamate tert-butyl N-(4-hydroxy-3-methylcyclohexyl)carbamate tert-butyl N-(5-aminonaphthalen-1-yl)carbamate tert-butyl N-(5-{[(tert-butoxy)carbonyl]amino}-3-oxopentyl)c arbamate BOC-GAMMA-ABU-OH Boc-L-glutamic acid 1-tert-butyl ester Boc-L-Glutamic acid 1-benzyl ester N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-D-Glu-OBzl Boc-L-Glutamic acid 1-Butanol BOC-GLU(OBZL)-OH DCHA BOC-GLU-LYS-LYS-MCA BOC-STA-OH BOC-GLU(OSU)-OBZL

BOC-NH-(CH2)4-OH

BOC-ABU(4)-OL

BOC-4-AMINOBUTANOL

4-(TERT-BUTOXYCARBONYLAMINO)-1-BUTANOL

4-(BOC-AMINO)-1-BUTANOL

N-(4-HYDROXYBUTYL)CARBAMIC ACID TERT-BUTYL ESTER

N-BOC-4-AMINOBUTANOL

N-T-BUTOXYCARBONYL-4-AMINO-1-BUTANOL

N-T-BUTOXYCARBONYL-DELTA-AMINO-N-BUTYL ALCOHOL

TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE

tert-butyl N-(4-hydroxybutyl)carbamate (en)

tert-Butyl (4-hydroxybutyl)carbaMate

1,1-DiMethylethyl (4-Hydroxybutyl)carbaMate

N-(4-Hydroxybutyl)carbaMic Acid 1,1-DiMethylethyl Ester

N-Boc-4-aminobutanol tert-Butyl N-(4-Hydroxybutyl)carbamate N-(4-Hydroxybutyl)carbamic Acid tert-Butyl Ester

N-Boc-4-Amino-1-butanol

4-(Boc-amino)-1-butanol >=98.0% (GC)

Boc-4-Abu-ol

4-(Boc-amino)-1-butanol≥ 98% (HPLC)

4-Boc-Abu-ol

Carbamic acid, (4-hydroxybutyl)-, 1,1-dimethylethyl ester

4-(tert-Butoxycarbonylamino)-1-butanol &gt

1,?4-?Butane-?1,?1,?2,?2,?3,?3,?4,?4-?d8-?diamine,?dihydrochloride?(9CI)

Carbamic acid, N-(4-hydroxybutyl)-, 1,1-dimethylethyl ester

4-(tert-ButoxycarbonylaMino)-1-butanol USP/EP/BP

(4-hydroxybutyl)carbamic acid tert-butyl ester

4-BOC AMINO BUTANOL

75178-87-9

75179-87-9

CH33CO2CNHCH24OH

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