Meprednisone

ChemicalBook > CAS DataBase List > Meprednisone

Product Name: Meprednisone
CAS No.: 1247-42-3
Chemical Name: Meprednisone
Synonyms: BETAPAR;Sch 4358;betalone;betapred;NSC 527579;betanisona;bitanisone;deltisonab;MEPREDNISONE;PREDNISONE(RG)
CBNumber: CB5453496
Molecular Formula: C22H28O5
Formula Weight: 372.45
MOL File: 1247-42-3.mol

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Meprednisone Property

Melting point:: 204-2060C
alpha: D +200° (dioxane)
Boiling point:: 574.4±50.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.38±0.70(Predicted)
form: Solid
color: White
InChI: InChI=1/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/s3
InChIKey: PIDANAQULIKBQS-RULBMMQNNA-N
SMILES: [C@@]12([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@]1([H])[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H] |&1:0,3,5,11,16,18,28,r|

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Safety

HS Code: 2937290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M225040
Product name: Meprednisone
Packaging: 5mg
Price: $130
Updated: 2021/12/16

TRC

Product number: M225040
Product name: Meprednisone
Packaging: 10mg
Price: $230
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134345
Product name: Betapar(Meprednisone)
Purity: >99%
Packaging: 1g
Price: $1654.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134345
Product name: Betapar(Meprednisone)
Purity: >99%
Packaging: 100mg
Price: $559.3
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 71202
Product name: Meprednisone
Packaging: 10mg
Price: $620
Updated: 2021/12/16

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Meprednisone Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Betapar,Parke Davis,US,1970

Uses

Corticosteroid.

Uses

Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone. [1]The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to a

Definition

ChEBI: Meprednisone is a 21-hydroxy steroid.

Manufacturing Process

16β-Methylprednisone 21-acetate (0.5 g), when hydrolyzed by means of aqueous alcoholic potassium bicarbonate yields 16β-ethylprednisone. An alternative method of the preparation of the compound of this example is as follows. Bacillus sphaericus var. fusifermis (A.T.C.C. 7055) is incubated on a nutrient agar (composed of Bacto-beef extract, 3 g; Bacto-peptone, 5 9; sodium chloride, 8 9; agar, 15 g; and tap water, 1 liter) for 24 hours at 28°C.
To 100 ml of a sterile nutrient broth (composed of Bacto-beef extract, 3 9; Bacto-peptone, 5 9; per liter of tap water) in a 300 ml flask is added one loopful of the incubated culture and the broth mixture is further incubated for 24 hours at 28°C on a shaking machine. The broth culture so obtained is employed as an inoculum (1%). Into each of ten flasks containing 100 ml of sterile nutrient broth is added 1 ml of the inoculum. The flasks are agitated on a rotary shaker for 8 hours at 28°C at 240 strokes per minute. After this growth period, a solution of 25 mg of 16β-methylcortisonein 0.5 ml of methanol is aseptically added to each flask which in turn is reshaken and incubated for an additional 24 hours. The final pH is 7.8.
The contents of the flasks are then combined and extracted 3 times with two liters of chloroform per extraction. The combined chloroform extracts are evaporated to dryness yielding 310 mg of crude product. The crude steroid is purified by chromatography on a chromatographic system described by G.M. Shull, Abstracts of Papers of the 126th Meeting of the American Chemical Society, December 12-17, 1954, page 9a, paper No. 24. Chromatographic evaluation shows a quantitative conversion of the starting material to the diene when an authentic sample of the 16β-methylprednisone is used as a control. Alternatively, the crude product is recrystallized from acetone affording 225 mg of 16β-methylprednisone.

brand name

Betapar (Schering).

Therapeutic Function

Glucocorticoid

Meprednisone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Meprednisone manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Meprednisone 1247-42-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500
Release date: 2023-07-31

Shaanxi Dideu Medichem Co. Ltd

Product: Meprednisone 1247-42-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000Kg
Release date: 2024-08-08

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Meprednisone 1247-42-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50tons
Release date: 2023-08-28

1247-42-3, MeprednisoneRelated Search:

Prednisone Prednisolone CHLOROPHOSPHONAZO III Trimethyl borate Prednisolone phosphate sodium Methylprednisolone 6alpha-Methylprednisolone sodium succinate Prednisolone-21-acetate Methylprednisolone acetate Prednisone 21-acetate Hydrocortisone Dexamethasone-17-acetate 2-Allylcyclohexanone 1,4-PREGNADIEN-3,20-DIONE MEPREDNISONE USP(CRM STANDARD) MEPREDNISONE ACETATE 1,4-PREGNADIEN-16-BETA-METHYL-17,21-DIOL-3,11,20-TRIONE 21-ACETATE

(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

16-BETA-METHYLPREDNISONE

1,4-PREGNADIEN-16-BETA-METHYL-17,21-DIOL-3,11,20-TRIONE

MEPREDNISONE

0091-22-2081567

Prednisone BP93,USP25,

Meprednisone(16BetaMethylPrednisone)

16β-Methylprednisone

17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione

PREDNISONE(RG)

(16)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione

Methylprednisone

NSC 527579

Sch 4358

BETAPAR

Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16b)-

Meprednisone (200 mg)

Betapar(Meprednisone)

Meprednisone (Betapar)

Meprednisone Solution, 100ppm

11,20-trione,17,21-dihydroxy-16-beta-methyl-pregna-4-diene-3

16-beta-metilprednisone

betalone

betanisona

betapred

bitanisone

deltacortenebeta

deltisonab

lepicortin-beta

6a-Methylpredniso

21-tert-Butyldimethylsilyl 6&alpha

Meprednisone solution in methanol, 100ppm

Meprednisone USP/EP/BP

Meprednisone (1388005)

Meprednisone/Methylprednisone/Betalone

Prednisone Impurity 30

Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)-

1, 4-PREGNADIEN-16β-METHYL-17, 21-DIOL-3, 11, 20-TRIONE

C14880300 Meprednisone

Benzoyl Peroxide Impurity 10

1247-42-3

Betanisona

Inhibitors

Steroid and Hormone

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids

1247-42-3