1,2,4,5-Tetrafluorobenzene
- Product Name
- 1,2,4,5-Tetrafluorobenzene
- CAS No.
- 327-54-8
- Chemical Name
- 1,2,4,5-Tetrafluorobenzene
- Synonyms
- 1,2,4,5-TetrafL;p-Tetrafluorobenzene;1,2,4,5-Tetrafluorbenzol;1,2,4,5-Tetrafluorobenzyl;1,2,4,5-TETRAFLUOROBENZENE;2,3,5,6-Tetrafluorobenzene;benzene,1,2,4,5-tetrafluoro-;1,2,4,5-Tetrafluorobenzene,98%;1,2,4,5-Tetrafluorobenzene 99%;1,2,4,5-TETRAFLUOROBENZENE, 99+%
- CBNumber
- CB5454897
- Molecular Formula
- C6H2F4
- Formula Weight
- 150.07
- MOL File
- 327-54-8.mol
1,2,4,5-Tetrafluorobenzene Property
- Melting point:
- 4 °C (lit.)
- Boiling point:
- 90 °C (lit.)
- Density
- 1.344 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.407(lit.)
- Flash point:
- 61 °F
- storage temp.
- Sealed in dry,2-8°C
- form
- clear liquid
- color
- Colorless to Almost colorless
- Specific Gravity
- 1.344
- Water Solubility
- Not miscible or difficult to mix in water.
- BRN
- 1909052
- InChI
- InChI=1S/C6H2F4/c7-3-1-4(8)6(10)2-5(3)9/h1-2H
- InChIKey
- SDXUIOOHCIQXRP-UHFFFAOYSA-N
- SMILES
- C1(F)=CC(F)=C(F)C=C1F
- CAS DataBase Reference
- 327-54-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1,2,4,5-tetrafluoro-(327-54-8)
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36/37/39-37/39-33-7/9
- RIDADR
- UN 1993 3/PG 2
- WGK Germany
- 3
- Hazard Note
- Flammable/Irritant
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29039990
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T11657
- Product name
- 1,2,4,5-Tetrafluorobenzene
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- T1029
- Product name
- 1,2,4,5-Tetrafluorobenzene
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $18
- Updated
- 2025/07/31
- Product number
- T1029
- Product name
- 1,2,4,5-Tetrafluorobenzene
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- T310995
- Product name
- 1,2,4,5-Tetrafluorobenzene
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0015502
- Product name
- 1,2,4,5-TETRAFLUOROBENZENE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1054.05
- Updated
- 2021/12/16
1,2,4,5-Tetrafluorobenzene Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
It is employed as intermediate in organic synthesis. It is also used as pharmaceutical intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 29, p. 3042, 1964 DOI: 10.1021/jo01033a061
Synthesis
First, 2,4-dichlorofluorobenzene was used as a raw material and nitrated in the presence of 98% concentrated sulfuric acid at 20-40℃ to introduce a nitro group at a specific position on the benzene ring, generating 2,4-dichloro-5-fluoronitrobenzene. After purification by toluene extraction, solvent recovery under normal pressure, and vacuum distillation (120-130℃/8 mmHg), anhydrous potassium fluoride was used as the fluorinating agent to carry out a nucleophilic aromatic substitution reaction (Halex reaction) in a polar aprotic solvent at a high temperature of 180-200℃. The fraction with a boiling point of 88-92℃ was collected in time by "reaction-distillation". Through the simultaneous substitution of two chlorine atoms and the nitro group by fluorine atoms, 1,2,4,5-tetrafluorobenzene was finally obtained.
1,2,4,5-Tetrafluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,4,5-Tetrafluorobenzene Suppliers
- Tel
- 0570-8880359 15957008695
- 17950926@qq.com
- Country
- China
- ProdList
- 6
- Advantage
- 58
- Tel
- 19951442182
- sales@aribopharm.com
- Country
- China
- ProdList
- 1723
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 11777
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
View Lastest Price from 1,2,4,5-Tetrafluorobenzene manufacturers
- Product
- 1,2,4,5-Tetrafluorobenzene 327-54-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-10
- Product
- 1,2,4,5-Tetrafluorobenzene 327-54-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- 1,2,4,5-Tetrafluorobenzene 327-54-8
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26