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FENFLURAMINE

Product Name
FENFLURAMINE
CAS No.
458-24-2
Chemical Name
FENFLURAMINE
Synonyms
EQUINE;Acino;Pesos;S-768;C06996;Obedrex;Adipomin;Ponderex;Pondimin;Rotondin
CBNumber
CB1325500
Molecular Formula
C12H16F3N
Formula Weight
231.26
MOL File
458-24-2.mol
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FENFLURAMINE Property

Melting point:
170°C
Boiling point:
bp12 108-112°
Density 
1.0950 (estimate)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
pKa 9.10 (Uncertain)
form 
Oil
color 
Colourless to Pale Yellow
Stability:
Hygroscopic
CAS DataBase Reference
458-24-2
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
16-36/37-45
Hazardous Substances Data
458-24-2(Hazardous Substances Data)
Toxicity
LD50 i.p. in mice: 144 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
F247600
Product name
DL-Fenfluramine
Packaging
250mg
Price
$145
Updated
2021/12/16
TRC
Product number
F247600
Product name
DL-Fenfluramine
Packaging
2.5g
Price
$1155
Updated
2021/12/16
AHH
Product number
MT-51753
Product name
Fenfluramine
Purity
98%
Packaging
0.1g
Price
$690
Updated
2021/12/16
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FENFLURAMINE Chemical Properties,Usage,Production

Description

Fenfluramine is the only marketed anorectic agent that exerts its appetite depressant effect via a serotoninrgic mechanism. Its major metabolite, norfenfluramine, is believed to be the main active form in humans .

Originator

Obenon,Neofarma

Uses

Anorexic.

Definition

ChEBI: A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reu take pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding ehavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertensio .

Manufacturing Process

38.5 parts of (trifluoromethyl-3'-phenyl)-1-oximino-2-propane in 550 parts of ethanol (with ammonia) was hydrogenated under pressure of hydrogen 90 kg with a catalyst nickel Reney (20 parts). After a completion of reaction to the reaction mixture was added 1000 parts of water and 300 parts of hydrochloric acid. The mixture was concentrated in vacuo and extracted with 450 parts of ether. To an aqueous phase was added the sodium carbonate and the mixture was extracted with 500 parts of ether. Organic phase was concentrated in vacuo to obtain 29 g of 1-(meta-trifluoromethyl-phenyl)-2-ethylaminopropane. B.P. 96°C at 17 mm.

brand name

Pondimin (Robins).

Therapeutic Function

Anorexic

World Health Organization (WHO)

Fenfluramine, dexfenfluramine and phentermine were approved individually more than 20 years ago in the USA for single-drug, short-term treatment of obesity. The manufacturers of fenfluramine and dexfenfluramine have since voluntarily withdrawn both products from the market worldwide. Phentermine remains available.

Synthesis

Fenfluramine is prepared by reductive alkylation of norfenfluramine with acetaldehyde . The nor compound is obtained by catalytic hydrogenation of the oxime made from 3-trifluoromethlyphenyl acetone (Eq. 2).

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FENFLURAMINE Suppliers

458-24-2, FENFLURAMINERelated Search:


  • FENFLURAMINE
  • AURORA KA-7683
  • AURORA KA-7684
  • 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane
  • 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
  • Acino
  • Adipomin
  • N-Ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine
  • N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine
  • Obedrex
  • Pesos
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-
  • Ponderax PA
  • Ponderex
  • Pondimin
  • Rotondin
  • ethyl(alpha-methyl-3-trifluoromethylphenethyl)amine
  • FENCLORIN
  • N-Ethyl-α-methyl-3-(tfifluoromethyl)benzeneethanamine
  • Phenfluoramine
  • n-ethyl-alpha-methyl-m-(trifluoromethyl)-phenethylamin
  • n-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine
  • Fenfluramin
  • N-Ethyl-3-trifluoromethyl-α-methylbenzeneethanamine
  • N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine
  • N-Ethyl-α-methyl-m-(trifluoromethyl)benzeneethanamine
  • dl-Fenfluramine
  • C06996
  • Methanol(Test Fenfluramine, 1.0 mg/mL)
  • Ponderal:Pon-derax
  • S-768
  • FenfluraMine API
  • EQUINE
  • Fenfluramine solution
  • Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-
  • FENFLURAMINE USP/EP/BP
  • Fenfluramine D6
  • 458-24-2