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Fenfluramine hydrochloride

Product Name
Fenfluramine hydrochloride
CAS No.
404-82-0
Chemical Name
Fenfluramine hydrochloride
Synonyms
FENFLURAMINE HCL;ponderal;ponderax;FENFLURAMINE HYDROCHLORIDE;FEBFLURAMINE HYDROCHLORIDE;phenfluoraminehydrochloride;rac Fenfluramine Hydrochloride;(+/-)-FENFLURAMINE HYDROCHLORIDE;Fenfluramine hydrochloride USP/EP/BP;FENFLURAMINE HYDROCHLORIDE MM(CRM STANDARD)
CBNumber
CB0314194
Molecular Formula
C12H17ClF3N
Formula Weight
267.72
MOL File
404-82-0.mol
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Fenfluramine hydrochloride Property

Melting point:
1660C
Boiling point:
108-112 °C(Press: 12 Torr)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
form 
A solid
Stability:
Hygroscopic
CAS DataBase Reference
404-82-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-23/24/25
Safety Statements 
7-16-36/37-45-36/37/39-22
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DA0295500
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 oral in rabbit: 50mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22491
Product name
3-trifluoromethyl-N-Ethylamphetamine (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
22491
Product name
3-trifluoromethyl-N-Ethylamphetamine (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
TRC
Product number
F245605
Product name
DL-FenfluramineHydrochloride
Packaging
1g
Price
$525
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002686
Product name
FENFLURAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$950
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002686
Product name
FENFLURAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
50MG
Price
$2500
Updated
2021/12/16
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Fenfluramine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Controlled substance. Anorexic

Definition

ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

brand name

Pondimin (Robins).

General Description

Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl

Fenfluramine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Fenfluramine hydrochloride Suppliers

Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4505
Advantage
50
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9912
Advantage
50
Taizhou Ruixin Chemical Co., Ltd.
Tel
0576-89085261 15867635987
Fax
0576-89085262
Email
jasonhu09@163.com
Country
China
ProdList
435
Advantage
50
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55477
Advantage
58
Alfa Chemistry
Tel
+1-5166625404
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
21317
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
29831
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22968
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
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View Lastest Price from Fenfluramine hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Fenfluramine hydrochloride 404-82-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Dideu Industries Group Limited
Product
Fenfluramine hydrochloride 404-82-0
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-03

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