Fenfluramine hydrochloride
- Product Name
- Fenfluramine hydrochloride
- CAS No.
- 404-82-0
- Chemical Name
- Fenfluramine hydrochloride
- Synonyms
- FENFLURAMINE HCL;ponderal;ponderax;FENFLURAMINE HYDROCHLORIDE;FEBFLURAMINE HYDROCHLORIDE;phenfluoraminehydrochloride;Fenfluramine HCl in Methanol;rac Fenfluramine Hydrochloride;(+/-)-FENFLURAMINE HYDROCHLORIDE;Fenfluramine HCl in Acetonitrile
- CBNumber
- CB0314194
- Molecular Formula
- C12H17ClF3N
- Formula Weight
- 267.72
- MOL File
- 404-82-0.mol
Fenfluramine hydrochloride Property
- Melting point:
- 1660C
- Boiling point:
- 108-112 °C(Press: 12 Torr)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
- form
- A solid
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 404-82-0(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-23/24/25
- Safety Statements
- 7-16-36/37-45-36/37/39-22
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DA0295500
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 oral in rabbit: 50mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22491
- Product name
- 3-trifluoromethyl-N-Ethylamphetamine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 22491
- Product name
- 3-trifluoromethyl-N-Ethylamphetamine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- F245605
- Product name
- DL-FenfluramineHydrochloride
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- API0002686
- Product name
- FENFLURAMINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $950
- Updated
- 2021/12/16
- Product number
- API0002686
- Product name
- FENFLURAMINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $2500
- Updated
- 2021/12/16
Fenfluramine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
Controlled substance. Anorexic
Definition
ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
brand name
Pondimin (Robins).
General Description
Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl
Fenfluramine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fenfluramine hydrochloride manufacturers
- Product
- Fenfluramine hydrochloride 404-82-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11