ChemicalBook > CAS DataBase List > 2,6-DIMETHOXYBENZONITRILE
2,6-DIMETHOXYBENZONITRILE
- Product Name
- 2,6-DIMETHOXYBENZONITRILE
- CAS No.
- 16932-49-3
- Chemical Name
- 2,6-DIMETHOXYBENZONITRILE
- Synonyms
- AKOS 227-44;2,6-DIMETHOXYBENZONI;2,6 methoxybenzonitrile;2,6-dimethoxy-benzonitril;2,6-DIMETHOXYBENZONITRILE;Benzonitrile, 2,6-dimethoxy-;2,6-Dimethoxybenzonitrile,97%;2,6-Dimethoxybenzenecarbonitrile
- CBNumber
- CB5455607
- Molecular Formula
- C9H9NO2
- Formula Weight
- 163.17
- MOL File
- 16932-49-3.mol
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2,6-DIMETHOXYBENZONITRILE Property
- Melting point:
- 119-123 °C
- Boiling point:
- 310 °C
- Density
- 1.2021 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Crystalline Powder
- color
- Light beige
- CAS DataBase Reference
- 16932-49-3(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22
- Safety Statements
- 36/37-36-26
- Hazard Note
- Irritant
- HS Code
- 29269095
- Toxicity
- rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 17, 1953.
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- R427128
- Product name
- 2,6-DIMETHOXYBENZONITRILE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- R427128
- Product name
- 2,6-DIMETHOXYBENZONITRILE
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $179
- Updated
- 2024/03/01
TRC
- Product number
- D480305
- Product name
- 2,6-Dimethoxybenzonitrile
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4637-1-W4
- Product name
- 2,6-Dimethoxybenzonitrile
- Purity
- 97%
- Packaging
- 10g
- Price
- $56
- Updated
- 2021/12/16
AK Scientific
- Product number
- J56451
- Product name
- 2,6-Dimethoxybenzonitrile
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
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2,6-DIMETHOXYBENZONITRILE Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 3, p. 293, 1955
Tetrahedron, 49, p. 10843, 1993 DOI: 10.1016/S0040-4020(01)80238-6
Synthesis
68-12-2
151-10-0
16932-49-3
At 0 °C, n-butyllithium (1.67 M hexane solution, 2.9 mL, 4.8 mmol) was slowly added dropwise to a tetrahydrofuran (THF, 5 mL) solution of 1,3-dimethoxybenzene (0.55 g, 4.0 mmol). After the reaction mixture was stirred at 0 °C for 2 h, N,N-dimethylformamide (DMF, 0.34 mL, 4.4 mmol) was added and stirring was continued at 0 °C for 2 h. The reaction mixture was then mixed with N,N-dimethylformamide (DMF, 0.34 mL, 4.4 mmol). Subsequently, ammonia solution (8 mL, 120 mmol) and dihydroammonium iodide (DIH, 0.91 g, 2.4 mmol) were added to the reaction system and the mixture was transferred to room temperature and stirred for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium sulfite solution (15 mL) and then extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=3:1) to afford pure 2,6-dimethoxybenzonitrile in 94% yield as a colorless solid.
References
[1] Tetrahedron, 2011, vol. 67, # 5, p. 958 - 964
[2] Synlett, 2010, # 10, p. 1562 - 1566
2,6-DIMETHOXYBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DIMETHOXYBENZONITRILE manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2,6-DIMETHOXYBENZONITRILE 16932-49-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
Career Henan Chemical Co
- Product
- 2,6-DIMETHOXYBENZONITRILE 16932-49-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12
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