6-CYANO-1-TETRALONE

Product Name: 6-CYANO-1-TETRALONE
CAS No.: 90401-84-6
Chemical Name: 6-CYANO-1-TETRALONE
Synonyms: 6-CYANO-1-TETRALONE;5,6,7,8-Tetrahydro-5-oxo-2-naphthonitrile;6-CYANO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE;5-oxo-7,8-dihydro-6H-naphthalene-2-carbonitrile;5-OXO-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBONITRILE;5-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile
CBNumber: CB5458471
Molecular Formula: C11H9NO
Formula Weight: 171.2
MOL File: 90401-84-6.mol

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6-CYANO-1-TETRALONE Property

Boiling point:: 343℃
Density: 1.19
Flash point:: 161℃
storage temp.: 2-8°C
Appearance: Yellow to brown Solid

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T263699
Product name: 5-OXO-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBONITRILE
Purity: AldrichCPR
Packaging: 5MG
Price: $30.7
Updated: 2025/07/31

TRC

Product number: C984460
Product name: 6-Cyano-1-tetralone
Packaging: 500mg
Price: $160
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003603
Product name: 6-CYANO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE
Purity: 95.00%
Packaging: 250MG
Price: $166.95
Updated: 2021/12/16

Matrix Scientific

Product number: 072964
Product name: 6-Cyano-1-tetralone
Purity: 95+%
Packaging: 1g
Price: $230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154218
Product name: 6-CYANO-1-TETRALONE
Packaging: 1g
Price: $235
Updated: 2021/12/16

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6-CYANO-1-TETRALONE Chemical Properties,Usage,Production

Uses

6-Cyano-1-tetralone is a reactant in the preparation of imidazolylmethylenetetrahydronaphthalene derivatives as aldosterone synthase inhibitors.

Synthesis

557-21-1

144464-64-2

90401-84-6

Step 2: Synthesis of 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile A solution of 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (11.5 g, 39.0 mmol) prepared in the previous step was degassed with zinc cyanide (2.7 g, 23.5 mmol) in anhydrous dimethylformamide (100 mL) and reacted under nitrogen atmosphere. To the reaction mixture was added tetrakis(triphenylphosphine)palladium(0) (1.7 g, 1.5 mmol), which was again degassed and kept under nitrogen atmosphere. The reaction mixture was stirred at 135 °C overnight. Subsequently, tetrakis(triphenylphosphine)palladium (0) (171 mg) was added supplementally and stirring was continued for 4 hours. Upon completion of the reaction, the reaction mixture was filtered through Celite? and rinsed with ethyl acetate. The filtrate was washed with water, the organic layer was separated and dried over anhydrous sodium sulfate. The dried organic layer was filtered and concentrated in vacuum to give 8.1 g of crude product. The crude product was purified by silica gel column chromatography using a gradient elution of 5% to 15% ethyl acetate/hexane, resulting in 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (2.8 g, 41% yield) with a mass spectrometry (ES) m/z 172 [M + H]+.

References

[1] Patent: US2008/45578, 2008, A1. Location in patent: Page/Page column 18
[2] Patent: US2008/45556, 2008, A1. Location in patent: Page/Page column 41-42

6-CYANO-1-TETRALONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CYANO-1-TETRALONE Suppliers

China 47 India 3 United Kingdom 4 United States 11 Global 65

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90401-84-6, 6-CYANO-1-TETRALONERelated Search:

Benzonitrile, 4-acetyl-3-methyl- (9CI) 4-Acetylbenzonitrile 4-Chlorobenzaldehyde 6-CYANO-1-TETRALONE

6-CYANO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE

6-CYANO-1-TETRALONE

5,6,7,8-Tetrahydro-5-oxo-2-naphthonitrile

5-Oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile

5-oxo-7,8-dihydro-6H-naphthalene-2-carbonitrile

5-OXO-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBONITRILE

90401-84-6

Benzocycles