3,5-Dibromo-2-hydroxypyrazine
- Product Name
- 3,5-Dibromo-2-hydroxypyrazine
- CAS No.
- 21943-15-7
- Chemical Name
- 3,5-Dibromo-2-hydroxypyrazine
- Synonyms
- 3,5-bromopyrazin-2-ol;3,5-DIBROMO-PYRAZIN-2-OL;3,5-dibromo-2(1H)-Pyrazinone;3,5-dibromo-1H-pyrazin-2-one;3,5-DIBROMO-2-HYDROXYPYRAZINE;2-Hydroxy-3,5-dibromopyrazine;2(1H)-Pyrazinone, 3,5-dibromo-;3,5-DibroMo-2-hydroxypyrazine, 95+%;3,5-Dibromo-2-hydroxypyrazine ISO 9001：2015 REACH
- CBNumber
- CB5460276
- Molecular Formula
- C4H2Br2N2O
- Formula Weight
- 253.88
- MOL File
- 21943-15-7.mol
3,5-Dibromo-2-hydroxypyrazine Property
- Melting point:
- 174-178°C
- Density
- 2.53±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 8.35±0.60(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C4H2Br2N2O/c5-2-1-7-4(9)3(6)8-2/h1H,(H,7,9)
- InChIKey
- NHVGHXUOFWEOSN-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(Br)N=C1Br
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D425525
- Product name
- 3,5-Dibromo-2-pyrazinone
- Packaging
- 25g
- Price
- $825
- Updated
- 2021/12/16
- Product number
- 072226
- Product name
- 3,5-Dibromo-2-hydroxypyrazine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- OR61104
- Product name
- 3,5-Dibromo-2-hydroxypyrazine
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 4H56-9-X6
- Product name
- 3,5-Dibromo-2-hydroxypyrazine
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- FD139570
- Product name
- 3,5-Dibromopyrazin-2-ol
- Packaging
- 2g
- Price
- $76
- Updated
- 2021/12/16
3,5-Dibromo-2-hydroxypyrazine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
3,5-Dibromo-pyrazinol ,is a pyrazine derivative that can be used as a potential building block in chemical synthesis. It can also be used in SRN1 mechanism in heteroaromatic nucleophilic substitution.
Synthesis
24241-18-7
21943-15-7
Preparation of compound 36a: 3,5-dibromopyrazin-2-ol To a stirred solution of 3,5-dibromopyrazin-2-amine (30 g, 0.12 mol) in acetic acid (300 mL) was added sulfuric acid (50 mL) dropwise at 15-25 °C. Subsequently, a solution of sodium nitrite (16.6 g, 0.24 mol) in water (100 mL) was added dropwise to the resulting solution over a period of 1.5 hours at 10-15°C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 10-15 °C for 1 hour. The reaction mixture was poured into water (3L) and extracted with ethyl acetate (1L x 3). The organic layers were combined, washed sequentially with saturated sodium bicarbonate solution (1L×3) and brine (1L), dried with anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3,5-dibromo-2-hydroxypyrazine (36a) as a yellow solid (24 g, 79.4% yield). 1H NMR (400 MHz, CDCl3): δ 7.44 (s, 1H).
References
[1] Patent: WO2010/16005, 2010, A1. Location in patent: Page/Page column 144
3,5-Dibromo-2-hydroxypyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dibromo-2-hydroxypyrazine manufacturers
- Product
- 3,5-Dibromo-2-hydroxypyrazine 21943-15-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28
- Product
- 3,5-Dibromo-2-hydroxypyrazine 21943-15-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01