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Megestrol

Product Name
Megestrol
CAS No.
3562-63-8
Chemical Name
Megestrol
Synonyms
C07120;Megestro;MEGESTROL;Megestrol USP/EP/BP;Megestrol in Methanol;megestrol solution,100ppm;Megestrol acetate EP Impurity B;Megestrol 100 μg/ml Acetonitrile;Metesterone acetate EP impurity B;4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
CBNumber
CB5465978
Molecular Formula
C22H30O3
Formula Weight
342.47
MOL File
3562-63-8.mol
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Megestrol Property

Melting point:
207-208 °C(Solv: ethyl ether (60-29-7); acetone (67-64-1))
Boiling point:
500.4±50.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
13.00±0.70(Predicted)
color 
White to Off-White
CAS DataBase Reference
3562-63-8(CAS DataBase Reference)
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Safety

Hazardous Substances Data
3562-63-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M208040
Product name
Megestrol
Packaging
50mg
Price
$145
Updated
2021/12/16
Usbiological
Product number
M2860-55B
Product name
Megestrol
Packaging
500ul
Price
$306
Updated
2021/12/16
TRC
Product number
M208040
Product name
Megestrol
Packaging
500mg
Price
$1165
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006501
Product name
MEGESTROL
Purity
95.00%
Packaging
500MG
Price
$1686.3
Updated
2021/12/16
ChemScene
Product number
CS-0013903
Product name
Megestrol
Purity
99.69%
Packaging
100mg
Price
$200
Updated
2021/12/16
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Megestrol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.

Indications

As a representitive of the compounds of the class of progestins, this drug is used for various forms of cancer, in particular cancer of the breast, kidneys, and others.

Definition

ChEBI: A 3-oxo Delta4-steroid that is pregna-4,6-diene-3,20-dione substituted by a hydroxy group at position 17.

brand name

Megace (Bristol-Myers Squibb); Megace (Par);Citestrol;Co-ervonum;Combiquens;Femagest;Kombiquens;Megecat;Megeron;Megestat;Menoquens;Neo-delpregnin;Niaestine;Niagestine;Novaquin;Novokvens;Novolina;Novoquens;Oracolnal;Ovaban;Ovarid;Pallace;Serial 28;Volidan;Volplan.

World Health Organization (WHO)

Megestrol acetate, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, megestrol acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and megestrol remains available in some countries for contraceptive purposes. In other countries its use is restricted to anticancer treatment. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Synthesis

Megestrol, 17|á-hydroxy-6|á-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6¨CC7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydride in the presence of p-toluenesulfonic acid.

Megestrol Preparation Products And Raw materials

Raw materials

Preparation Products

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Megestrol Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
Tel
18858184290; 18858184290
Fax
0086-571-28313105
Email
sales@zyterpharm.com
Country
China
ProdList
48
Advantage
49
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
VOT INTERNATIONAL BUSINESS CO.,LTD
Tel
0536-2456718
Fax
0536-8231856
Country
China
ProdList
226
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
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View Lastest Price from Megestrol manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Megestrol 3562-63-8
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
Megestrol 3562-63-8
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Shaanxi Dideu Medichem Co. Ltd
Product
Megestrol 3562-63-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26

3562-63-8, MegestrolRelated Search:


  • 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione
  • 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3
  • 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
  • 17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE
  • MEGESTROL
  • 17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione
  • Megestrol (base and/or unspecified salts)
  • C07120
  • megestrol solution,100ppm
  • (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • Megestrol acetate EP Impurity B
  • Megestrol Acetate Impurity 2(Megestrol Acetate EP Impurity B)(Megestrol)
  • Megestro
  • Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
  • Megestrol Acetate Impurity 2(Megestrol Acetate EP Impurity B)
  • Metesterone acetate EP impurity B
  • Megestrol USP/EP/BP
  • Megestrol in Methanol
  • Megestrol 100 μg/ml Acetonitrile
  • 3562-63-8
  • Hormone Drugs
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • 3562-63-8