ChemicalBook > CAS DataBase List > MGV354
MGV354
- Product Name
- MGV354
- CAS No.
- 1852495-86-3
- Chemical Name
- MGV354
- Synonyms
- MGV354;(Rac)-MGV354;MGV354|MGV 354;(Rac)-MGV354, 10 mM in DMSO;pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular;1-[6-(3-{[4-(1-cyclopropanecarbonylpiperidin-4-yl)-2-methylphenyl]amino}-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl]-5-methyl-1H-pyrazole-4-carboxylic acid
- CBNumber
- CB54668179
- Molecular Formula
- C35H37N5O3
- Formula Weight
- 575.71
- MOL File
- 1852495-86-3.mol
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MGV354 Property
- Boiling point:
- 824.8±65.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- solubility
- DMSO : 100 mg/mL (173.70 mM; Need ultrasonic)
- pka
- 3.20±0.25(Predicted)
- form
- Solid
- color
- White to off-white
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MGV354 Chemical Properties,Usage,Production
Biological Activity
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1].
References
[1]. Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570.
MGV354 Preparation Products And Raw materials
Raw materials
Preparation Products
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MGV354 Suppliers
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- +1-781-999-5354 +1-00000000000
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