SHIN1

Product Name: SHIN1
CAS No.: 2146095-85-2
Chemical Name: SHIN1
Synonyms: SHIN1;RZ-2994;SHIN 1New;SHIN1(RZ-2994);SHIN1, 10 mM in DMSO;SHIN1,RZ2994,SHIN-1,RZ 2994,Inhibitor,SHIN 1,inhibit;{5-[6-amino-3,5-dimethyl-4-(propan-2-yl)-1H,4H-pyrano[2,3-c]pyrazol-4-yl]-[1,1'-biphenyl]-3-yl}methanol;6-amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-Amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
CBNumber: CB54672640
Molecular Formula: C24H24N4O2
Formula Weight: 400.47
MOL File: 2146095-85-2.mol

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SHIN1 Property

Boiling point:: 683.6±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 11.54±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 6998
Product name: SHIN1
Purity: ≥98%(HPLC)
Packaging: 5
Price: $319
Updated: 2021/12/16

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SHIN1 Chemical Properties,Usage,Production

Uses

SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.

storage

Store at -20°C

References

[1] Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114

SHIN1 Preparation Products And Raw materials

Raw materials

Preparation Products

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SHIN1 Suppliers

China 57 United States 4 Global 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16027
Advantage: 64

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2988
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1946
Advantage: 55

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

Shanghai Akasaka Biotechnology Co., Ltd.

Tel: 15121162054
Country: CHINA
ProdList: 635
Advantage: 58

2146095-85-2, SHIN1Related Search:

SHIN1

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-

RZ-2994

SHIN1,RZ2994,SHIN-1,RZ 2994,Inhibitor,SHIN 1,inhibit

6-Amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

{5-[6-amino-3,5-dimethyl-4-(propan-2-yl)-1H,4H-pyrano[2,3-c]pyrazol-4-yl]-[1,1'-biphenyl]-3-yl}methanol

SHIN1, 10 mM in DMSO

6-amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

SHIN 1New

SHIN1(RZ-2994)

6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile

2146095-85-2