GLX351322
- Product Name
- GLX351322
- CAS No.
- 835598-94-2
- Chemical Name
- GLX351322
- Synonyms
- CS-2871;GLX 351322;GLX-351322;GLX351322,GLX-351322,GLX 351322,NADPH Oxidase,NOX,Inhibitor,inhibit;Ethyl 2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate;Ethyl 2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate , GLX351322;4H-Cyclopenta[b]thiophene-3-carboxylic acid, 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-, ethyl ester
- CBNumber
- CB54672882
- Molecular Formula
- C21H25N3O5S
- Formula Weight
- 431.51
- MOL File
- 835598-94-2.mol
GLX351322 Property
- solubility
- DMSO:20.0(Max Conc. mg/mL);46.35(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.32(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.76(Max Conc. mM)
Ethanol:4.0(Max Conc. mg/mL);9.27(Max Conc. mM) - form
- A crystalline solid
- color
- White to off-white
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2546
- Product name
- GLX351322
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $95.3
- Updated
- 2023/06/20
- Product number
- SML2546
- Product name
- GLX351322
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $385
- Updated
- 2023/06/20
- Product number
- CS-0018088
- Product name
- GLX351322
- Purity
- 99.48%
- Packaging
- 25mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0018088
- Product name
- GLX351322
- Purity
- 99.48%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0018088
- Product name
- GLX351322
- Purity
- 99.48%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
GLX351322 Chemical Properties,Usage,Production
Biological Activity
GLX351322 is an inhibitor of NADPH oxidase 4 (NOX4). It can inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with IC50 of 5 μM.
in vitro
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC 50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells ( IC 50 , 40 μM).
in vivo
GLX351322 (3.8 mg/kg/day, po) ameliorates HFD-induced hyperglycemia in mice.
target
Target | Value |
NOX4 (Cell-free assay) | 5 μM |
GLX351322 Preparation Products And Raw materials
Raw materials
Preparation Products
GLX351322 Suppliers
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