Urolithin B
- Product Name
- Urolithin B
- CAS No.
- 1139-83-9
- Chemical Name
- Urolithin B
- Synonyms
- Urolithin B;Uro-B;AURORA 226;NeolithicB;Urolithinum;Uricosuric B;3-Hydroxy-6H<;AKOS BBS-00008028;3-hydroxy urolithin;Urolithin B, 10 mM in DMSO
- CBNumber
- CB5467477
- Molecular Formula
- C13H8O3
- Formula Weight
- 212.2
- MOL File
- 1139-83-9.mol
Urolithin B Property
- Melting point:
- 247 °C
- Boiling point:
- 432.6±24.0 °C(Predicted)
- Density
- 1.395±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 9.03±0.20(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C13H8O3/c14-8-5-6-10-9-3-1-2-4-11(9)13(15)16-12(10)7-8/h1-7,14H
- InChIKey
- WXUQMTRHPNOXBV-UHFFFAOYSA-N
- SMILES
- C12=CC(O)=CC=C1C1=CC=CC=C1C(=O)O2
- LogP
- 2.947 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1649
- Product name
- Urolithin B
- Purity
- ≥95% (HPLC)
- Packaging
- 10mg
- Price
- $111
- Updated
- 2025/07/31
- Product number
- OTV000001
- Product name
- 3-Hydroxy-6H-benzo[c]chromen-6-one
- Purity
- AldrichCPR
- Packaging
- 250mg
- Price
- $41.5
- Updated
- 2024/03/01
- Product number
- SML1649
- Product name
- Urolithin B
- Purity
- ≥95% (HPLC)
- Packaging
- 50mg
- Price
- $447
- Updated
- 2025/07/31
- Product number
- U847005
- Product name
- Urolithin B
- Packaging
- 10g
- Price
- $1060
- Updated
- 2021/12/16
- Product number
- 62554
- Product name
- Urolithin B
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
Urolithin B Chemical Properties,Usage,Production
Uses
Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.
Definition
ChEBI: Urolithin B is a member of coumarins.
Biochem/physiol Actions
Urolithin B is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.
Synthesis
1143-62-0
1139-83-9
GENERAL METHODS: Urolithin A-C (30a-c, 1.0 eq.) was dissolved in methyl ether and cooled to 0 °C under argon protection. Boron tribromide (BBr3) was slowly added and the reaction progress was monitored by thin layer chromatography (TLC) until the starting material was completely consumed. Subsequently, the reaction mixture was acidified by the addition of 2N hydrochloric acid solution and extracted with ethyl acetate (EtOAc) to obtain the crude product. Finally, the crude product was purified by size exclusion chromatography to obtain the target compound 3-hydroxy-6H-benzo[c]benzopyran-6-one.
in vivo
Urolithin B (50 mg/kg; ip; once daily for 4 days) inhibits microglial activation in LPS-injected mouse brains, under neuroinflammatory condition[1].
Urolithin B (10 μg/day; mini-osmotic pump delivery, 28 days) induces muscle hypertrophy and reduces muscle atrophy after sciatic nerve transection in mice[2].
IC 50
Human Endogenous Metabolite
References
[1] Tetrahedron, 2013, vol. 69, # 44, p. 9277 - 9283
[2] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 433 - 444
[3] Journal of Organic Chemistry, 2017, vol. 82, # 10, p. 5080 - 5095
[4] ChemMedChem, 2010, vol. 5, # 9, p. 1616 - 1630
Urolithin B Preparation Products And Raw materials
Raw materials
Preparation Products
Urolithin B Suppliers
- Tel
- --
- Fax
- --
- aurora@aurorafinechemicals.com
- Country
- Austria
- ProdList
- 6625
- Advantage
- 72
View Lastest Price from Urolithin B manufacturers
- Product
- Urolithin B 1139-83-9
- Price
- US $1150.00/g
- Min. Order
- 1g
- Purity
- 99 %
- Supply Ability
- 500 Kg
- Release date
- 2025-11-24
- Product
- Urolithin B 1139-83-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-21
- Product
- Urolithin B 1139-83-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-05-12