ChemicalBook > CAS DataBase List > Urolithin B

Urolithin B

Product Name
Urolithin B
CAS No.
1139-83-9
Chemical Name
Urolithin B
Synonyms
Urolithin B;Uro-B;AURORA 226;NeolithicB;Urolithinum;Uricosuric B;3-Hydroxy-6H<;AKOS BBS-00008028;3-hydroxy urolithin;Urolithin B, 10 mM in DMSO
CBNumber
CB5467477
Molecular Formula
C13H8O3
Formula Weight
212.2
MOL File
1139-83-9.mol
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Urolithin B Property

Melting point:
247 °C
Boiling point:
432.6±24.0 °C(Predicted)
Density 
1.395±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
9.03±0.20(Predicted)
form 
powder
color 
white to beige
Stability:
Hygroscopic
InChI
InChI=1S/C13H8O3/c14-8-5-6-10-9-3-1-2-4-11(9)13(15)16-12(10)7-8/h1-7,14H
InChIKey
WXUQMTRHPNOXBV-UHFFFAOYSA-N
SMILES
C12=CC(O)=CC=C1C1=CC=CC=C1C(=O)O2
LogP
2.947 (est)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2932209090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1649
Product name
Urolithin B
Purity
≥95% (HPLC)
Packaging
10mg
Price
$111
Updated
2025/07/31
Sigma-Aldrich
Product number
OTV000001
Product name
3-Hydroxy-6H-benzo[c]chromen-6-one
Purity
AldrichCPR
Packaging
250mg
Price
$41.5
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1649
Product name
Urolithin B
Purity
≥95% (HPLC)
Packaging
50mg
Price
$447
Updated
2025/07/31
TRC
Product number
U847005
Product name
Urolithin B
Packaging
10g
Price
$1060
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
62554
Product name
Urolithin B
Packaging
1g
Price
$490
Updated
2021/12/16
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Urolithin B Chemical Properties,Usage,Production

Uses

Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.

Definition

ChEBI: Urolithin B is a member of coumarins.

Biochem/physiol Actions

Urolithin B is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.

Synthesis

1143-62-0

1139-83-9

GENERAL METHODS: Urolithin A-C (30a-c, 1.0 eq.) was dissolved in methyl ether and cooled to 0 °C under argon protection. Boron tribromide (BBr3) was slowly added and the reaction progress was monitored by thin layer chromatography (TLC) until the starting material was completely consumed. Subsequently, the reaction mixture was acidified by the addition of 2N hydrochloric acid solution and extracted with ethyl acetate (EtOAc) to obtain the crude product. Finally, the crude product was purified by size exclusion chromatography to obtain the target compound 3-hydroxy-6H-benzo[c]benzopyran-6-one.

in vivo

Urolithin B (50 mg/kg; ip; once daily for 4 days) inhibits microglial activation in LPS-injected mouse brains, under neuroinflammatory condition[1].
Urolithin B (10 μg/day; mini-osmotic pump delivery, 28 days) induces muscle hypertrophy and reduces muscle atrophy after sciatic nerve transection in mice[2].

IC 50

Human Endogenous Metabolite

References

[1] Tetrahedron, 2013, vol. 69, # 44, p. 9277 - 9283
[2] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 433 - 444
[3] Journal of Organic Chemistry, 2017, vol. 82, # 10, p. 5080 - 5095
[4] ChemMedChem, 2010, vol. 5, # 9, p. 1616 - 1630

Urolithin B Preparation Products And Raw materials

Raw materials

Preparation Products

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Urolithin B Suppliers

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View Lastest Price from Urolithin B manufacturers

R&D Scientific Inc.
Product
Urolithin B 1139-83-9
Price
US $1150.00/g
Min. Order
1g
Purity
99 %
Supply Ability
500 Kg
Release date
2025-11-24
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Urolithin B 1139-83-9
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-21
Shenzhen Nexcon Pharmatechs Ltd.
Product
Urolithin B 1139-83-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-05-12

1139-83-9, Urolithin BRelated Search:

Urolithin C 3-methoxy-6H-benzo[c]chromen-6-one Urolithin D 3,8,9,10-tetrahydroxy urolithin Urolithin A 3,8,10-trihydroxy urolithin 3,4,8,9,10-Pentahydroxy Urolithin Dibenzofuran 1-Hydroxybenzotriazole 2-Benzoxazolinone

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  • 3-hydroxy urolithin
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  • Urolithin B, 10 mM in DMSO
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