6-Methylthioguanine

Product Name: 6-Methylthioguanine
CAS No.: 1198-47-6
Chemical Name: 6-Methylthioguanine
Synonyms: NSC 29420;TIMTEC-BB SBB000228;6-Methylthioguanine;S-Methyl-6-thioguanine;S6-Methyl-6-thioguanine;2-Amino-6-methylthiopurine;Mercaptopurine Impurity 29;6-Methylthioguanine USP/EP/BP;2-AMINO-6-METHYLMERCAPTOPURINE;6-Methylthio-7H-purine-2-amine
CBNumber: CB5468494
Molecular Formula: C6H7N5S
Formula Weight: 181.22
MOL File: 1198-47-6.mol

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6-Methylthioguanine Property

Melting point:: 235.5°C
Density: 1.403 (estimate)
refractive index: 1.4606 (estimate)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: solid
color: White to Off-White

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 24/25-39-26
WGK Germany: 3
HS Code: 29335995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9546
Product name: 2-Amino-6-methylmercaptopurine
Purity: ≥95%
Packaging: 100mg
Price: $126
Updated: 2024/03/01

Usbiological

Product number: 017448
Product name: 6-Methylthioguanine
Packaging: 250mg
Price: $496
Updated: 2021/12/16

TRC

Product number: M330720
Product name: 6-Methylthioguanine
Packaging: 1g
Price: $660
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0027598
Product name: 2-AMINO-6-METHYLMERCAPTOPURINE
Purity: 95.00%
Packaging: 250MG
Price: $779.63
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0027598
Product name: 2-AMINO-6-METHYLMERCAPTOPURINE
Purity: 95.00%
Packaging: 2.5G
Price: $2255
Updated: 2021/12/16

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6-Methylthioguanine Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline powder

Uses

2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.

Uses

As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.

Definition

ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine.

Biochem/physiol Actions

2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.

6-Methylthioguanine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methylthioguanine Suppliers

Belgium 2 Canada 1 China 47 Germany 1 India 1 Japan 1 Russia 1 Switzerland 1 United Kingdom 4 United States 8 Global 67

J & K SCIENTIFIC LTD.

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Nanjing Chemlin Chemical Co., Ltd

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Chemsky (shanghai) International Co.,Ltd

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Shandong Xiya Chemical Co., Ltd

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Chengdu Ai Keda Chemical Technology Co., Ltd.

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Thermo Fisher Scientific

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9ding chemical ( Shanghai) Limited

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Shanghai TaoSu Biochemical Technology Co., Ltd.

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Huainan Kedi Chemical Factory

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1198-47-6, 6-MethylthioguanineRelated Search:

8-AZA-6-HYDROXY-2-MERCAPTOPURINE 6-thioinosine-5'-triphosphate 6,8-DIHYDROXY-2-METHYLMERCAPTOPURINE 2-Amino-6-mercaptopurine-13C2,15N 6-N-HEPTYLMERCAPTOPURINE 1,9-DIHYDRO-6H-PURINE-6-THIONE 2-AMINO-9-(2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)-6-THIOPURINE 6-(Methylthio)purine 2-AMINO-6-HYDROXY-8-MERCAPTOPURINE 1,7,8,9-tetrahydro-8-thioxo-6H-purin-6-one 6-METHYLMERCAPTOPURINE RIBOSIDE 6-Thioguanosine hydrate 2-MERCAPTOPURINE 6-METHYL-D3-MERCAPTOPURINE 2,6-Dithiopurine 1H-Imidazole-4-carboxylic acid 6-thioinosine 5'-monophosphate 6-thioinosine 2',3',5'-triacetate

1H-Purin-2-amine, 6-(methylthio)-

2-Amino-6-methylthiopurine

6-(Methylsulfanyl)-1H-purin-2-amine

6-Methylthioguanine

TIMTEC-BB SBB000228

6-(METHYLSULFANYL)-7H-PURIN-2-YLAMINE

2-AMINO-6-METHYLMERCAPTOPURINE

2-AMINO-6-METHYLMERCAPTOPURINE 95%

2-Amino-6-(methylthio)-9H-purine

6-(Methylthio)-9H-purine-2-amine

6-Methylthio-7H-purine-2-amine

2-Amino-6-methylmercaptopurine,95%

NSC 29420

S6-Methyl-6-thioguanine

S-Methyl-6-thioguanine

6-(methylthio)-1H-purin-2-amine

2-Amino-6-methylmercaptopurine-[13C, d3] (Solution)

9H-Purin-2-amine, 6-(methylthio)-

Mercaptopurine Impurity 29

6-Methylthioguanine USP/EP/BP

6-(methylsulfanyl)-7H-purin-2-amine

6-(Methylthio)-7H-purin-2-amine

1198-47-6

C6H7N5S

Biochemicals and Reagents

BioChemical

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Mutagenesis Research Chemicals, Sulfur & Selenium Compounds

Bases & Related Reagents

Heterocycles

Metabolites & Impurities

Mutagenesis Research Chemicals

Nucleotides

Sulfur & Selenium Compounds