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ARA-S

Product Name
ARA-S
CAS No.
187224-29-9
Chemical Name
ARA-S
Synonyms
ARA-S;N-ARACHIDONOYL L-SERINE;N-[1-OXO-(5Z,8Z,11Z,14Z-EICOSATETRAENYL)]-L-SERINE;L-Serine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-
CBNumber
CB5470587
Molecular Formula
C23H37NO4
Formula Weight
391.54
MOL File
187224-29-9.mol
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ARA-S Property

Boiling point:
607.6±55.0 °C(Predicted)
Density 
1.027±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml
pka
3.26±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10005455
Product name
N-Arachidonoyl-L-Serine
Purity
≥98%
Packaging
1mg
Price
$20
Updated
2024/03/01
Cayman Chemical
Product number
10005455
Product name
N-Arachidonoyl-L-Serine
Purity
≥98%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
10005455
Product name
N-Arachidonoyl-L-Serine
Purity
≥98%
Packaging
10mg
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
10005455
Product name
N-Arachidonoyl-L-Serine
Purity
≥98%
Packaging
25mg
Price
$160
Updated
2024/03/01
TRC
Product number
A765110
Product name
N-Arachidonoyl-L-serine
Packaging
100mg
Price
$395
Updated
2021/12/16
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ARA-S Chemical Properties,Usage,Production

Description

Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature. N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model. However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC. The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.

Uses

N-Arachidonoyl-L-serine is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and invivo in mice model of traumatic brain injury. (1) Exhibits neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways (2)

Definition

ChEBI: N-arachidonoyl-L-serine is an N-acyl-amino acid resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-serine. It is an endocannabinoid-like lipid isolated from bovine brains. It has a role as a cannabinoid receptor agonist, a vasodilator agent, a pro-angiogenic agent, a neuroprotective agent and a mammalian metabolite. It is functionally related to an arachidonic acid and a L-serine. It is a conjugate acid of a N-arachidonoyl-L-serine(1-).

ARA-S Preparation Products And Raw materials

Raw materials

Preparation Products

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ARA-S Suppliers

China 25 Switzerland 1 United States 6 Global 32
Alfa Chemistry
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1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
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United States
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9171
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Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
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24072
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
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58
United States Biological
Tel
--
Fax
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Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

187224-29-9, ARA-SRelated Search:

R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE ANANDAMIDE ARA-S NAGLY N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)-L-ALANINE

  • N-ARACHIDONOYL L-SERINE
  • N-[1-OXO-(5Z,8Z,11Z,14Z-EICOSATETRAENYL)]-L-SERINE
  • ARA-S
  • L-Serine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-
  • 187224-29-9
  • Cannabinoid receptor