CINPA 1
- Product Name
- CINPA 1
- CAS No.
- 102636-74-8
- Chemical Name
- CINPA 1
- Synonyms
- CINPA 1;CINPA1, 10 mM in DMSO;Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate;Carbamic acid, N-[5-[2-(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester;Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI);ethyl N-{2-[2-(diethylamino)acetyl]-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl}carbamate
- CBNumber
- CB54723186
- Molecular Formula
- C23H29N3O3
- Formula Weight
- 395.49
- MOL File
- 102636-74-8.mol
CINPA 1 Property
- Boiling point:
- 545.8±50.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 100 mM; Ethanol: 100 mM
- form
- A crystalline solid
- pka
- 13.44±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29110
- Product name
- CINPA1
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29110
- Product name
- CINPA1
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29110
- Product name
- CINPA1
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 5605
- Product name
- CINPA1
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 5605
- Product name
- CINPA1
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $521
- Updated
- 2021/12/16
CINPA 1 Chemical Properties,Usage,Production
Uses
CINPA 1 is an inhibitor of constitutive androstane receptor (CAR) which regulates the expression of genes involved in drug metabolism.
Biological Activity
CINPA1 is a ligand-binding domain (LBD)-targeting constitutive androstane receptor (CAR) inhibitor th at prevents CAR recruitment to promoter regions of regulated genes (by >85%; 1 μM CINPA1 against 0.1 μM CITCO-induced CAR recruitment to CYP2B6 or CYP3A4 promoters; human hepatocytes) by altering CAR-coregulator interactions. CINPA1 inhibits CAR-mediated transcription in a potent (IC50 = 70 nM; HepG2-hCAR1 CYP2B6-luc reporter cells) and selective manner with only weak PXR antagonist potency (68% inhibition by 18 μM CINPA1 against 5 μM rifampicin; HepG2-PXR reporter cells) and no cytotoxicity or agonist/antagonist activity toward FXR, GR, LXRα/β, PPARγ, RXRα/β, VDR.
storage
Store at -20°C
CINPA 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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