ChemicalBook > CAS DataBase List > CP-24879 HYDROCHLORIDE

CP-24879 HYDROCHLORIDE

Product Name: CP-24879 HYDROCHLORIDE
CAS No.: 10141-51-2
Chemical Name: CP-24879 HYDROCHLORIDE
Synonyms: CP-24879;CP-24879 HCl;p-isopentoxyaniline;CP-24879 HYDROCHLORIDE;Benzenamine, 4-(3-methylbutoxy)-;P-ISOPENTOXYANILINE HYDROCHLORIDE;a€￠ Benzenamine, 4-(3-methylbutoxy)-;CP-24879 hydrochloride, 10 mM in DMSO;4-(Isopentyloxy)aniline hydrochloride;P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE
CBNumber: CB5472334
Molecular Formula: C11H18ClNO
Formula Weight: 215.72
MOL File: 10141-51-2.mol

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CP-24879 HYDROCHLORIDE Property

Melting point:: 154-159 °C
storage temp.: room temp
solubility: DMSO: 22 mg/mL
form: solid
color: off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9115
Product name: CP-24879 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $222
Updated: 2025/07/31

Sigma-Aldrich

Product number: C9115
Product name: CP-24879 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $808
Updated: 2023/01/07

Cayman Chemical

Product number: 10120
Product name: CP 24,879 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2024/03/01

Cayman Chemical

Product number: 10120
Product name: CP 24,879 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $133
Updated: 2024/03/01

Cayman Chemical

Product number: 10120
Product name: CP 24,879 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $234
Updated: 2024/03/01

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CP-24879 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].

Biochem/physiol Actions

delta5/delta6 (Δ5/Δ6) desaturase inhibitor.

in vivo

CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice^[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life^[1].

Animal Model:	Chow-fed and EFAD Balb/C mice (N = 5/group) ^[1]
Dosage:	3 mg/kg
Administration:	IP, three times a day, for 6 or 4 days
Result:	Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).

Animal Model:	Swiss-Webster mice (male, 25 g) ^[1]
Dosage:	33 mg/kg
Administration:	IV in the tail vein, once (Pharmacokinetic Analysis)
Result:	Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T_1/2 = 59 min).

References

[1] Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. DOI:10.1016/s0006-2952(97)00665-5
[2] [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. DOI:10.1136/gutjnl-2012-303179
[3] [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442. DOI:10.1073/pnas.2006828117

CP-24879 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-24879 HYDROCHLORIDE Suppliers

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10141-51-2, CP-24879 HYDROCHLORIDERelated Search:

AKOS B033290 N-(4-Chlorobenzyl)-4-(2-cyclohexylethoxy)aniline CP-24879 HYDROCHLORIDE N-[4-(2,4-Dichlorophenoxy)butyl]-4-(isopentyloxy)-aniline 3-CHLORO-4-(3-METHOXY-3-METHYL-BUTOXY)-PHENYLAMINE 3-chloro-4-[(4-methylpentan-2-yl)oxy]aniline N-(3-Chlorobenzyl)-4-(isopentyloxy)aniline N-[2-(2-Chlorophenoxy)propyl]-4-(2-cyclohexylethoxy)aniline 3-CHLORO-4-(ISOPENTYLOXY)ANILINE sibanomicin 3-CHLORO-4-(2-CYCLOHEXYLETHOXY)ANILINE N-(2-Chlorobenzyl)-4-(2-cyclohexylethoxy)aniline

4-(3-METHYLBUTOXY)-BENZENAMINE HYDROCHLORIDE

p-isopentoxyaniline

P-ISOPENTOXYANILINE HYDROCHLORIDE

P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE

CP-24879 HYDROCHLORIDE

Benzenamine, 4-(3-methylbutoxy)-

a€￠ Benzenamine, 4-(3-methylbutoxy)-

CP-24879

CP-24879 hydrochloride >=98% (HPLC), powder

CP-24879 HCl

CP24879,CP-24879,Fatty acid desaturase inhibitor,Anti-inflammatory active,Ferroptosis,CP 24879,CP 24879 hydrochloride,inhibit,CP24879 hydrochloride,Non-alcoholic steatohepatitis,Inhibitor

CP-24879 hydrochloride, 10 mM in DMSO

4-(Isopentyloxy)aniline hydrochloride

10141-51-2

C11H18NOCl

BioChemical

Biochemicals and Reagents

D5/D6-Desaturase

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

D to K