ChemicalBook > CAS DataBase List > CP-24879 HYDROCHLORIDE

CP-24879 HYDROCHLORIDE

Product Name
CP-24879 HYDROCHLORIDE
CAS No.
10141-51-2
Chemical Name
CP-24879 HYDROCHLORIDE
Synonyms
CP-24879;CP-24879 HCl;p-isopentoxyaniline;CP-24879 HYDROCHLORIDE;Benzenamine, 4-(3-methylbutoxy)-;P-ISOPENTOXYANILINE HYDROCHLORIDE;a€￠ Benzenamine, 4-(3-methylbutoxy)-;CP-24879 hydrochloride, 10 mM in DMSO;4-(Isopentyloxy)aniline hydrochloride;P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE
CBNumber
CB5472334
Molecular Formula
C11H18ClNO
Formula Weight
215.72
MOL File
10141-51-2.mol
More
Less

CP-24879 HYDROCHLORIDE Property

Melting point:
154-159 °C
storage temp. 
room temp
solubility 
DMSO: 22 mg/mL
form 
solid
color 
off-white
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C9115
Product name
CP-24879 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$222
Updated
2025/07/31
Sigma-Aldrich
Product number
C9115
Product name
CP-24879 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$808
Updated
2023/01/07
Cayman Chemical
Product number
10120
Product name
CP 24,879 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$31
Updated
2024/03/01
Cayman Chemical
Product number
10120
Product name
CP 24,879 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$133
Updated
2024/03/01
Cayman Chemical
Product number
10120
Product name
CP 24,879 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$234
Updated
2024/03/01
More
Less

CP-24879 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].

Biochem/physiol Actions

delta5/delta6 (Δ5/Δ6) desaturase inhibitor.

in vivo

CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1].

Animal Model:Chow-fed and EFAD Balb/C mice (N = 5/group) [1]
Dosage:3 mg/kg
Administration:IP, three times a day, for 6 or 4 days
Result:Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).
Animal Model:Swiss-Webster mice (male, 25 g) [1]
Dosage:33 mg/kg
Administration:IV in the tail vein, once (Pharmacokinetic Analysis)
Result:Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min).

References

[1] Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. DOI:10.1016/s0006-2952(97)00665-5
[2] [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. DOI:10.1136/gutjnl-2012-303179
[3] [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442. DOI:10.1073/pnas.2006828117

CP-24879 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CP-24879 HYDROCHLORIDE Suppliers

China 44 Switzerland 2 United States 6 Global 52
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
AXXORA, LLC
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.com
Country
Switzerland
ProdList
1104
Advantage
80

10141-51-2, CP-24879 HYDROCHLORIDERelated Search:

AKOS B033290 N-(4-Chlorobenzyl)-4-(2-cyclohexylethoxy)aniline CP-24879 HYDROCHLORIDE N-[4-(2,4-Dichlorophenoxy)butyl]-4-(isopentyloxy)-aniline 3-CHLORO-4-(3-METHOXY-3-METHYL-BUTOXY)-PHENYLAMINE 3-chloro-4-[(4-methylpentan-2-yl)oxy]aniline N-(3-Chlorobenzyl)-4-(isopentyloxy)aniline N-[2-(2-Chlorophenoxy)propyl]-4-(2-cyclohexylethoxy)aniline 3-CHLORO-4-(ISOPENTYLOXY)ANILINE sibanomicin 3-CHLORO-4-(2-CYCLOHEXYLETHOXY)ANILINE N-(2-Chlorobenzyl)-4-(2-cyclohexylethoxy)aniline

  • 4-(3-METHYLBUTOXY)-BENZENAMINE HYDROCHLORIDE
  • p-isopentoxyaniline
  • P-ISOPENTOXYANILINE HYDROCHLORIDE
  • P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE
  • CP-24879 HYDROCHLORIDE
  • Benzenamine, 4-(3-methylbutoxy)-
  • a€￠ Benzenamine, 4-(3-methylbutoxy)-
  • CP-24879
  • CP-24879 hydrochloride >=98% (HPLC), powder
  • CP-24879 HCl
  • CP24879,CP-24879,Fatty acid desaturase inhibitor,Anti-inflammatory active,Ferroptosis,CP 24879,CP 24879 hydrochloride,inhibit,CP24879 hydrochloride,Non-alcoholic steatohepatitis,Inhibitor
  • CP-24879 hydrochloride, 10 mM in DMSO
  • 4-(Isopentyloxy)aniline hydrochloride
  • 10141-51-2
  • C11H18NOCl
  • BioChemical
  • Biochemicals and Reagents
  • D5/D6-Desaturase
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • D to K