CP-424,174

Product Name: CP-424,174
CAS No.: 210825-31-3
Chemical Name: CP-424,174
Synonyms: CP-424,174;CP-424,174 >=98% (HPLC);CP 424174, 10 mM in DMSO;N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide;CP424174,IL-1β,NLRP3,Inhibitor,CP 424174,CP-424174,Inflammasome,inhibit,NOD-like Receptor (NLR);N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide;Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)-
CBNumber: CB54741315
Molecular Formula: C22H29ClN2O4S
Formula Weight: 452.99
MOL File: 210825-31-3.mol

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CP-424,174 Property

Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
form: powder
pka: 4.67±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0347
Product name: CP-424,174
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0347
Product name: CP-424,174
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2024/03/01

Tocris

Product number: 6107
Product name: CP424174
Purity: ≥98%(HPLC)
Packaging: 10
Price: $117
Updated: 2021/12/16

Tocris

Product number: 6107
Product name: CP424174
Purity: ≥98%(HPLC)
Packaging: 50
Price: $393
Updated: 2021/12/16

TRC

Product number: C781493
Product name: CP424174
Packaging: 1mg
Price: $75
Updated: 2021/12/16

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CP-424,174 Chemical Properties,Usage,Production

Uses

CP-424174 is a reversible inhibitor against IL-1β processing with an IC50 of 210 nM.CP-424174 indirectly inhibits NLRP3[1].

Biochem/physiol Actions

CP-424,174 is a cytokine release inhibitory drugs (CRID) that inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. It is quite possible that similarly to CP-456,773 (termed CRID3), CP-424,174 inhibits both NLRP3 and AIM2 inflammasomes by preventing ASC oligomerisation.

References

[1] Alex G Baldwin, et al. Inhibiting the Inflammasome: A Chemical Perspective. J Med Chem DOI:10.1021/acs.jmedchem.5b01091

CP-424,174 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-424,174 Suppliers

China 32 Japan 1 United Kingdom 1 United States 7 USA 1 Global 42

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210825-31-3, CP-424,174Related Search:

CP-424,174

N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide

Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)-

CP-424,174 >=98% (HPLC)

N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide

CP424174,IL-1β,NLRP3,Inhibitor,CP 424174,CP-424174,Inflammasome,inhibit,NOD-like Receptor (NLR)

CP 424174, 10 mM in DMSO

210825-31-3