Uses
ChemicalBook > CAS DataBase List > (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide

(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide

Uses
Product Name
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
CAS No.
2101517-69-3
Chemical Name
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
Synonyms
BL 918 NEW;BL-918 ，S0819;BL 918 - Bio-X;BL-918 (BL918);BL-918, 10 mM in DMSO;(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide;Benzeneacetamide, α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-, (αR)-;inhibit,disease,BL-918,cytoprotective,BL 918,BL918,Autophagy,kinase,autophagic,Unc-51 like kinase,Orally,Parkinson’s,ULK,Inhibitor
CBNumber
CB54747731
Molecular Formula
C23H15F8N3OS
Formula Weight
533.4369256
MOL File
2101517-69-3.mol
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(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Property

Density 
1.508±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 250 mg/mL (468.66 mM)
form 
A solid
pka
11.13±0.70(Predicted)
color 
White to off-white
InChIKey
BDBWQANRZRCMMD-DETXXQSHNA-N
SMILES
C(NC1=CC=C(F)C=C1F)(=O)[C@H](NC(=S)NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C1=CC=CC=C1 |&1:11,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B595838
Product name
BL918
Packaging
5mg
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
BB165666
Product name
BL 918 NEW
Packaging
10mg
Price
$155
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0008598
Product name
BL-918
Purity
95.00%
Packaging
5MG
Price
$458.3
Updated
2021/12/16
Biosynth Carbosynth
Product number
BB165666
Product name
BL 918 NEW
Packaging
50mg
Price
$542.5
Updated
2021/12/16
AK Scientific
Product number
1916EP
Product name
(2R)-2-[[3,5-Bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide
Packaging
50mg
Price
$782
Updated
2021/12/16
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(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Chemical Properties,Usage,Production

Uses

BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.

Uses

BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.

in vivo

BL-918 (compound 33i; 20, 40, or 80 mg/kg/day; oral gavage; began 2 days before the first injection of saline/MPTP and continuously maintained for 5 days after the last injection of saline/MPTP) attenuates the loss of DA and its metabolites. BL-918 obviously decreases the levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA)[1].

Animal Model:Male C57BL/6 mice (eight-week old) weighing between 20 and 25 g[1]
Dosage:20, 40, or 80 mg/kg
Administration:Oral gavage; daily; began 2 days before the first injection of saline/MPTP and continuously maintained for 5 days after the last injection of saline/MPTP
Result:Attenuated the loss of DA and its metabolites.

IC 50

ULK1: 24.14 nM (EC50); ULK1: 0.719 μM (Kd)

(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Suppliers

China 46 United States 6 Global 52
Jingmo (Xiamen) Biotechnology Co., Ltd
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13621943973; 13621943973
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sales@jamxmpharmatech.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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028-81705658
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3003855609@qq.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4757
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 18101056239
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3193328036@qq.com
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China
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Rhawn Reagent
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amy@rhawn.cn
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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BOC Sciences
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2101517-69-3, (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamideRelated Search:


  • (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
  • BL-918 (BL918)
  • BL 918 NEW
  • inhibit,disease,BL-918,cytoprotective,BL 918,BL918,Autophagy,kinase,autophagic,Unc-51 like kinase,Orally,Parkinson’s,ULK,Inhibitor
  • Benzeneacetamide, α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-, (αR)-
  • BL 918 - Bio-X
  • BL-918, 10 mM in DMSO
  • BL-918 ，S0819
  • 2101517-69-3