2-Chloro-6-fluorobenzaldehyde

Product Name: 2-Chloro-6-fluorobenzaldehyde
CAS No.: 387-45-1
Chemical Name: 2-Chloro-6-fluorobenzaldehyde
Synonyms: 2-FLUORO-6-CHLORO BENZALDEHYDE;oro-6-fL;AKOS BBS-00003159;2-Chloro-6-fluoroben;OTAVA-BB BB7018801953;LABOTEST-BB LT00942032;Chloro-6-fluorobenzaldeh;2-Chlor-6-fluorbenzaldehyd;Chloro-6-fluorobenzaldehyde;2-Chloro-6 Florobenzaldehyde
CBNumber: CB5475502
Molecular Formula: C7H4ClFO
Formula Weight: 158.56
MOL File: 387-45-1.mol

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2-Chloro-6-fluorobenzaldehyde Property

Melting point:: 32-35 °C(lit.)
Boiling point:: 92 °C (10 mmHg)
Density: 1.3310 (estimate)
Flash point:: 215 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Crystalline Solid
color: White to yellow
Water Solubility: Insoluble
Sensitive: Air Sensitive
BRN: 2245530
InChI: InChI=1S/C7H4ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H
InChIKey: OACPOWYLLGHGCR-UHFFFAOYSA-N
SMILES: C(=O)C1=C(F)C=CC=C1Cl
CAS DataBase Reference: 387-45-1(CAS DataBase Reference)
EPA Substance Registry System: Benzaldehyde, 2-chloro-6-fluoro- (387-45-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 1
TSCA: T
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 141240
Product name: 2-Chloro-6-fluorobenzaldehyde
Purity: 95%
Packaging: 25g
Price: $51.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 141240
Product name: 2-Chloro-6-fluorobenzaldehyde
Purity: 95%
Packaging: 100g
Price: $86.1
Updated: 2025/07/31

TCI Chemical

Product number: C1424
Product name: 2-Chloro-6-fluorobenzaldehyde
Purity: >95.0%(GC)
Packaging: 10g
Price: $21
Updated: 2025/07/31

TRC

Product number: C366285
Product name: 2-Chloro-6-fluorobenzaldehyde
Packaging: 100mg
Price: $130
Updated: 2021/12/16

Oakwood

Product number: 001426
Product name: 2-Chloro-6-fluorobenzaldehyde
Purity: 97%
Packaging: 1g
Price: $9
Updated: 2021/12/16

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2-Chloro-6-fluorobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

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Uses

2-Chloro-6-fluorobenzaldehyde was used in the synthesis of novel copolymers of methyl 2-cyano-3-dihalophenyl-2-propenoates and styrene.

General Description

2-Chloro-6-fluorobenzaldehyde undergoes piperidine catalyzed Knoevenagel condensation reaction with methyl cyanoacetate to yield methyl 2-cyano-3-dihalophenyl-2-propenoate.

Synthesis

56456-50-9

387-45-1

GENERAL METHOD: A mixture of 2-chloro-6-fluorobenzyl alcohol (1.0 mmol), N-phenylglycine (0.0076 g, 0.05 mmol), CuBr2 (0.0112 g, 0.05 mmol), Na2CO3 (0.1060 g, 1.0 mmol), and TEMPO (0.0078 g, 0.05 mmol) was added to a 100 mL Schlenk tube with H2O (3.0 mL) was added to a 100 mL Schlenk tube. It was stirred vigorously for 0.5 h under reflux conditions in air. After completion of the reaction, the product was extracted with CH2Cl2 (3 x 2.0 mL). The organic phases were combined, washed with H2O (3.0 mL) and dried with anhydrous MgSO4. After vacuum concentration, the residue was purified by column chromatography to give 2-chloro-6-fluorobenzaldehyde. Isolated yield: 0.1080 g (90%).

References

[1] Synthetic Communications, 2008, vol. 38, # 15, p. 2638 - 2645
[2] Journal of the American Chemical Society, 2011, vol. 133, # 42, p. 16901 - 16910
[3] RSC Advances, 2014, vol. 4, # 90, p. 48777 - 48782
[4] Journal of Organic Chemistry, 2015, vol. 80, # 21, p. 11184 - 11188
[5] Synlett, 2015, vol. 26, # 6, p. 779 - 784

2-Chloro-6-fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

2-Chloro-6-fluorotoluene Benzyl dichloride

Preparation Products

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2-Chloro-6-fluorobenzaldehyde Suppliers

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View Lastest Price from 2-Chloro-6-fluorobenzaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-6-fluorobenzaldehyde 387-45-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-24

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-6-fluorobenzaldehyde 387-45-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-28

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Chloro-6-fluorobenzaldehyde 387-45-1
Price: US $65.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-07

387-45-1, 2-Chloro-6-fluorobenzaldehydeRelated Search:

2-Chloro-6-fluorobenzene-1-carbonyl chloride 2'-CHLORO-6'-FLUOROACETOPHENONE 6-CHLORO-2-FLUORO-3-METHYLBENZOYL CHLORIDE 2-Fluoro-6-chlorobenzamide 6-CHLORO-2-FLUORO-3-METHYLBENZAMIDE 2-CHLORO-6-FLUORO-3-METHYLBENZOYL CHLORIDE 2,3,4,5-TETRAFLUORO-6-CHLOROBENZOIC ACID 2-CHLORO-3,6-DIFLUOROBENZOYL CHLORIDE 2-Chloro-6-fluorobenzaldehyde 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE 2-CHLORO-3,6-DIFLUOROBENZAMIDE 6-CHLORO-2-FLUORO-3-METHYLBENZOIC ACID 2-CHLORO-6-FLUORO-3-METHYLBENZALDEHYDE 2'-CHLORO-6'-FLUORO-3'-METHYLACETOPHENONE 6'-CHLORO-2'-FLUORO-3'-METHYLACETOPHENONE 2-CHLORO-6-FLUORO-3-METHYLBENZOIC ACID 2,3-DICHLORO-6-FLUOROBENZALDEHYDE 2-CHLORO-3,6-DIFLUOROBENZOIC ACID

2-Choro-6-Fluoro Benzaldehyde

2-Chloro-6-fluorobenzaldehyde,min.96%

2-CHLORO-6-FLUOROBENZALDEHYDE,99%

2-Chloro-6-fluorobenzaldehyde97%

2-Chlor-6-fluorbenzaldehyd

4-Chloro-6-fluorobenzaldehyde

2-Chloro-6 Florobenzaldehyde

2-fluoro-6-chlorobenzene Methylal

2-Chloro-6-fluorobenzaldehyde, 95% 25GR

Benzaldehyde, 2-chloro-6-fluoro-

2-Chloro-6-fluorobenzaldehyde, min. 96%

2-Chloro-6-fluorobenzaldehyde,95%

2-Chloro-6-fluoroben

Chloro-6-fluorobenzaldeh

2-chloro -6-fluorobenzeneforMaldehyde

Chloro-6-fluorobenzaldehyde

2-chloro-6-fluoro-benzaldehyd

2-CHLORO-6-FLUOROBENZALDEHYDE

2-FLUORO-6-CHLORO BENZALDEHYDE

LABOTEST-BB LT00942032

OTAVA-BB BB7018801953

2-fluoro-6-chloroben-zoldehyde

AKOS BBS-00003159

oro-6-fL

2-Chloro-6-fluorobenzaldehyde &gt

387-45-1

559-88-2

Organic Building Blocks

C7

Carbonyl Compounds

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Aldehydes

C7

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Aryl Fluorinated Building Blocks

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FINE Chemical & INTERMEDIATES

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Fluorobenzene

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Fluorine series