ChemicalBook > CAS DataBase List > 2-Chloro-6-fluorobenzaldehyde

2-Chloro-6-fluorobenzaldehyde

Product Name
2-Chloro-6-fluorobenzaldehyde
CAS No.
387-45-1
Chemical Name
2-Chloro-6-fluorobenzaldehyde
Synonyms
2-FLUORO-6-CHLORO BENZALDEHYDE;oro-6-fL;AKOS BBS-00003159;2-Chloro-6-fluoroben;OTAVA-BB BB7018801953;LABOTEST-BB LT00942032;Chloro-6-fluorobenzaldeh;2-Chlor-6-fluorbenzaldehyd;Chloro-6-fluorobenzaldehyde;2-Chloro-6 Florobenzaldehyde
CBNumber
CB5475502
Molecular Formula
C7H4ClFO
Formula Weight
158.56
MOL File
387-45-1.mol
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2-Chloro-6-fluorobenzaldehyde Property

Melting point:
32-35 °C(lit.)
Boiling point:
92 °C (10 mmHg)
Density 
1.3310 (estimate)
Flash point:
215 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Crystalline Solid
color 
White to yellow
Water Solubility 
Insoluble
Sensitive 
Air Sensitive
BRN 
2245530
InChI
InChI=1S/C7H4ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H
InChIKey
OACPOWYLLGHGCR-UHFFFAOYSA-N
SMILES
C(=O)C1=C(F)C=CC=C1Cl
CAS DataBase Reference
387-45-1(CAS DataBase Reference)
EPA Substance Registry System
Benzaldehyde, 2-chloro-6-fluoro- (387-45-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
1
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
141240
Product name
2-Chloro-6-fluorobenzaldehyde
Purity
95%
Packaging
25g
Price
$51.7
Updated
2025/07/31
Sigma-Aldrich
Product number
141240
Product name
2-Chloro-6-fluorobenzaldehyde
Purity
95%
Packaging
100g
Price
$86.1
Updated
2025/07/31
TCI Chemical
Product number
C1424
Product name
2-Chloro-6-fluorobenzaldehyde
Purity
>95.0%(GC)
Packaging
10g
Price
$21
Updated
2025/07/31
TRC
Product number
C366285
Product name
2-Chloro-6-fluorobenzaldehyde
Packaging
100mg
Price
$130
Updated
2021/12/16
Oakwood
Product number
001426
Product name
2-Chloro-6-fluorobenzaldehyde
Purity
97%
Packaging
1g
Price
$9
Updated
2021/12/16
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2-Chloro-6-fluorobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

whitetoyellowcrystallinesoli

Uses

2-Chloro-6-fluorobenzaldehyde was used in the synthesis of novel copolymers of methyl 2-cyano-3-dihalophenyl-2-propenoates and styrene.

General Description

2-Chloro-6-fluorobenzaldehyde undergoes piperidine catalyzed Knoevenagel condensation reaction with methyl cyanoacetate to yield methyl 2-cyano-3-dihalophenyl-2-propenoate.

Synthesis

56456-50-9

387-45-1

GENERAL METHOD: A mixture of 2-chloro-6-fluorobenzyl alcohol (1.0 mmol), N-phenylglycine (0.0076 g, 0.05 mmol), CuBr2 (0.0112 g, 0.05 mmol), Na2CO3 (0.1060 g, 1.0 mmol), and TEMPO (0.0078 g, 0.05 mmol) was added to a 100 mL Schlenk tube with H2O (3.0 mL) was added to a 100 mL Schlenk tube. It was stirred vigorously for 0.5 h under reflux conditions in air. After completion of the reaction, the product was extracted with CH2Cl2 (3 x 2.0 mL). The organic phases were combined, washed with H2O (3.0 mL) and dried with anhydrous MgSO4. After vacuum concentration, the residue was purified by column chromatography to give 2-chloro-6-fluorobenzaldehyde. Isolated yield: 0.1080 g (90%).

References

[1] Synthetic Communications, 2008, vol. 38, # 15, p. 2638 - 2645
[2] Journal of the American Chemical Society, 2011, vol. 133, # 42, p. 16901 - 16910
[3] RSC Advances, 2014, vol. 4, # 90, p. 48777 - 48782
[4] Journal of Organic Chemistry, 2015, vol. 80, # 21, p. 11184 - 11188
[5] Synlett, 2015, vol. 26, # 6, p. 779 - 784

2-Chloro-6-fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

2-Chloro-6-fluorotoluene Benzyl dichloride

Preparation Products

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2-Chloro-6-fluorobenzaldehyde Suppliers

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View Lastest Price from 2-Chloro-6-fluorobenzaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-6-fluorobenzaldehyde 387-45-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-24
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-6-fluorobenzaldehyde 387-45-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-28
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Chloro-6-fluorobenzaldehyde 387-45-1
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-07

387-45-1, 2-Chloro-6-fluorobenzaldehydeRelated Search:

2-Chloro-6-fluorobenzene-1-carbonyl chloride 2'-CHLORO-6'-FLUOROACETOPHENONE 6-CHLORO-2-FLUORO-3-METHYLBENZOYL CHLORIDE 2-Fluoro-6-chlorobenzamide 6-CHLORO-2-FLUORO-3-METHYLBENZAMIDE 2-CHLORO-6-FLUORO-3-METHYLBENZOYL CHLORIDE 2,3,4,5-TETRAFLUORO-6-CHLOROBENZOIC ACID 2-CHLORO-3,6-DIFLUOROBENZOYL CHLORIDE 2-Chloro-6-fluorobenzaldehyde 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE 2-CHLORO-3,6-DIFLUOROBENZAMIDE 6-CHLORO-2-FLUORO-3-METHYLBENZOIC ACID 2-CHLORO-6-FLUORO-3-METHYLBENZALDEHYDE 2'-CHLORO-6'-FLUORO-3'-METHYLACETOPHENONE 6'-CHLORO-2'-FLUORO-3'-METHYLACETOPHENONE 2-CHLORO-6-FLUORO-3-METHYLBENZOIC ACID 2,3-DICHLORO-6-FLUOROBENZALDEHYDE 2-CHLORO-3,6-DIFLUOROBENZOIC ACID

  • 2-Choro-6-Fluoro Benzaldehyde
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  • 2-CHLORO-6-FLUOROBENZALDEHYDE,99%
  • 2-Chloro-6-fluorobenzaldehyde97%
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  • 2-Chloro-6 Florobenzaldehyde
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  • Chloro-6-fluorobenzaldeh
  • 2-chloro -6-fluorobenzeneforMaldehyde
  • Chloro-6-fluorobenzaldehyde
  • 2-chloro-6-fluoro-benzaldehyd
  • 2-CHLORO-6-FLUOROBENZALDEHYDE
  • 2-FLUORO-6-CHLORO BENZALDEHYDE
  • LABOTEST-BB LT00942032
  • OTAVA-BB BB7018801953
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  • 387-45-1
  • 559-88-2
  • Organic Building Blocks
  • C7
  • Carbonyl Compounds
  • Building Blocks
  • Aldehydes
  • Aldehydes
  • C7
  • Carbonyl Compounds
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Aromatics
  • Intermediates
  • FINE Chemical & INTERMEDIATES
  • Aromatic Aldehydes & Derivatives (substituted)
  • Benzaldehyde
  • Fluorobenzene
  • Other Fluorinated Organic Building Blocks
  • Fluorine series