ChemicalBook > CAS DataBase List > 3-HYDROXYPYRAZINE-2-CARBOXAMIDE
3-HYDROXYPYRAZINE-2-CARBOXAMIDE
- Product Name
- 3-HYDROXYPYRAZINE-2-CARBOXAMIDE
- CAS No.
- 55321-99-8
- Chemical Name
- 3-HYDROXYPYRAZINE-2-CARBOXAMIDE
- Synonyms
- Favipiravir Impurity;(3-BROMOPYRIDIN-4-...;T-1105, 10 mM in DMSO;Favipiravir intermediate;Favipiravir Desfluoro Impurity;3-HYDROXYPYRAZINE-2-CARBOXAMINE;3-HYDROXYPYRAZINE-2-CARBOXAMIDE;3-Hydroxy-2-pyrazinecarboxamide;Pyrazine-2-carboxamide, 3-hydroxy-;3-Hydroxypyrazine-2-carboxamide>
- CBNumber
- CB5478811
- Molecular Formula
- C5H5N3O2
- Formula Weight
- 139.11
- MOL File
- 55321-99-8.mol
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3-HYDROXYPYRAZINE-2-CARBOXAMIDE Property
- Melting point:
- ca 270℃
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Aqueous Base (Slightly)
- form
- Solid
- pka
- 10.69±0.40(Predicted)
- color
- Pale Brown to Brown
- λmax
- 348nm(lit.)
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C5H5N3O2/c6-4(9)3-5(10)8-2-1-7-3/h1-2H,(H2,6,9)(H,8,10)
- InChIKey
- SZPBAPFUXAADQV-UHFFFAOYSA-N
- SMILES
- C1(C(N)=O)=NC=CNC1=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- H1485
- Product name
- 3-Hydroxypyrazine-2-carboxamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H1485
- Product name
- 3-Hydroxypyrazine-2-carboxamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $148
- Updated
- 2025/07/31
TRC
- Product number
- D454150
- Product name
- 3,4-Dihydro-3-oxo-2-pyrazinecarboxamide
- Packaging
- 2.5g
- Price
- $185
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- JK594076
- Product name
- 3-Hydroxypyrazine-2-carboxamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
Chem-Impex
- Product number
- 37939
- Product name
- 3-Hydroxypyrazine-2-carboxamide,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 1G
- Price
- $44.8
- Updated
- 2021/12/16
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3-HYDROXYPYRAZINE-2-CARBOXAMIDE Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
Apart from biological importance of pyridine-2-carboxamide (picolinamide, pia) as well as of its derivatives such as 3-hydroxypyridine-2-carboxamide (3-OHpia), as ligands they have found their extensive application in coordina- tion chemistry in crystal engineering .
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 78, 1949 DOI: 10.1021/ja01169a023
Synthesis
131543-46-9
62009-47-6
55321-99-8
The general procedure for the synthesis of 3-hydroxypyrazine-2-carboxamide from the compound (CAS:131543-46-9) and 2-aminomalonamide was carried out as follows: firstly, diethylaminomalonate (in the form of hydrochloric acid) was dissolved in water, and pH was adjusted by adding sodium bicarbonate to a value greater than 7. Subsequently, an extraction operation was carried out, and the organic phase was evaporated under reduced pressure. The product obtained was quantitatively converted to aminodicarbonamide by treating the product with an aqueous ammonia solution at 80 °C overnight. The product obtained in this step does not require further purification and can be directly dissolved in water for the next reaction. Next, glyoxal sodium bisulfite hemihydrate was added to this aqueous solution and the reaction mixture was stirred at 90°C for 3 hours. After completion of the reaction, the reaction mixture was adjusted to alkaline with 58% NH4OH solution. A 30% H2O2 solution was added dropwise to the rapidly stirred cold solution at 0°C. The reaction mixture was allowed to stand at room temperature to induce precipitation of 2-hydroxy-3-carboxamide pyrazine. Finally, the solid product was collected in 63% yield and purified by partial recrystallization. References: [J. Med. Chem. 1983, 26, 283-86], [J. Heterocyclic Chem. 1979, 16, 193].
References
[1] Patent: WO2007/144686, 2007, A1. Location in patent: Page/Page column 129-130
[2] Patent: JP5739618, 2015, B2. Location in patent: Paragraph 0024
[3] Patent: US2018/141920, 2018, A1. Location in patent: Paragraph 0215; 0216; 0217; 0218; 0219; 0220; 0221; 0222
3-HYDROXYPYRAZINE-2-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-HYDROXYPYRAZINE-2-CARBOXAMIDE manufacturers
Wuhan Monad Medicine Tech Co.,LTD
- Product
- 3-HYDROXYPYRAZINE-2-CARBOXAMIDE 55321-99-8
- Price
- US $10.00/KG
- Min. Order
- 25Kg/Drum
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2021-04-20
Shaanxi Dideu Medichem Co. Ltd
- Product
- 3-hydroxypyrazine-2-carboxamide 55321-99-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
Career Henan Chemical Co
- Product
- 3-HYDROXYPYRAZINE-2-CARBOXAMIDE 55321-99-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01
55321-99-8, 3-HYDROXYPYRAZINE-2-CARBOXAMIDERelated Search:
Methyl 6-bromo-3-oxo-3,4-dihydropyrazine-2-carboxylate
6-Bromo-3-chloropyrazine-2-carbonitrile
3-Chloropyrazine-2-carbonitrile
Pyrazinecarboxamide, 3,6-difluoro- (9CI)
3-OXO-3,4-DIHYDROPYRAZINE-2-CARBONITRILE
2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-, coMpd. with N-cyclohexylcyclohexanaMine (1:1)
2-HYDROXYPYRAZINE
2-Pyrazinecarbonitrile, 3-fluoro-
Cefepime
3,6-DibroMopyrazine-2-carbonitrile
Pyrazinecarboxamide, 6-fluoro- (9CI)
Pyrazinecarboxamide, 5-fluoro-3,4-dihydro-3-oxo- (9CI)
3-HYDROXYPYRAZINE-2-CARBOXAMIDE
(3-METHOXY-PYRAZIN-2-YL)-MORPHOLIN-4-YL-METHANONE
5-Hydroxypyrazine-2-carboxamide
BUTTPARK 91\04-18
SALOR-INT L101621-1EA
3-HYDROXY-5,6-DIPHENYL-2-PYRAZINECARBOXAMIDE