HDAC6-IN-1
- Product Name
- HDAC6-IN-1
- CAS No.
- 1815580-06-3
- Chemical Name
- HDAC6-IN-1
- Synonyms
- SKLB-23bb;HDAC6-IN-1;SKLB 23bb,Histone deacetylases,Inhibitor,HDAC,inhibit,SKLB23bb,SKLB-23bb;N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide;Butanamide, N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-
- CBNumber
- CB54796658
- Molecular Formula
- C21H24N4O4
- Formula Weight
- 396.44
- MOL File
- 1815580-06-3.mol
HDAC6-IN-1 Property
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: Soluble
- form
- A solid
- pka
- 9.32±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0014660
- Product name
- SKLB-23bb
- Purity
- 98.49%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0014660
- Product name
- SKLB-23bb
- Purity
- 98.49%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
HDAC6-IN-1 Chemical Properties,Usage,Production
Uses
SKLB-23bb is an orally bioavailable and selective HDAC6 inhibitor with IC50 of less than 100 nM in most cell lines tested; it can be used to disrupt microtubule activity.
in vitro
SKLB-23bb has toxic effects at low submolar levels in a range of solid and hematological tumor cell lines. Unlike reported selective HDAC6 inhibition, SKLB-23bb is more potent against solid tumors. SKLB-23bb selectively inhibits intracellular HDAC6, but its antitumor activity is independent of HDAC6. It can bind to the colchicine site of β-tubulin and is a microtubule polymerization inhibitor. SKLB-23bb also can arrest tumor cells in the G2-M phase and induce apoptosis.
in vivo
In a solid tumor model, oral administration of SKLB-23bb can effectively inhibit tumor growth. It has favorable pharmacokinetic properties and is orally active.
target
| Target | Value |
| HDAC6 (Cell-based assay) | <100 nM |
HDAC6-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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