ChemicalBook > CAS DataBase List > MM 07
MM 07
- Product Name
- MM 07
- CAS No.
- 1876450-21-3
- Chemical Name
- MM 07
- Synonyms
- MM 07;MM 07 TFA;CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6)
- CBNumber
- CB54797084
- Molecular Formula
- C67H106N22O14S3
- Formula Weight
- 1539.91
- MOL File
- 1876450-21-3.mol
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MM 07 Property
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- pka
- 3.56±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Souble in water
- Sequence
- Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe (Disulfide bridge:Cys1-Cys6)
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N-Bromosuccinimide Price
Tocris
- Product number
- 7053
- Product name
- MM07
- Packaging
- 1
- Price
- $145
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573206
- Product name
- MM 07
- Packaging
- 100mg
- Price
- $1802
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573206
- Product name
- MM 07
- Packaging
- 250mg
- Price
- $3580.2
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573206
- Product name
- MM 07
- Packaging
- 1g
- Price
- $7136.6
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC12083
- Product name
- MM07
- Purity
- >98%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
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MM 07 Chemical Properties,Usage,Production
Uses
MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.
in vivo
MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr1]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr1]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr1]apelin 13 and MM 07 increases peak velocity above basal levels[1].
References
[1] Brame AL, et al. Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension. 2015 Apr;65(4):834-40. DOI:10.1161/HYPERTENSIONAHA.114.05099
MM 07 Preparation Products And Raw materials
Raw materials
Preparation Products
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