ELA-14 (human)

Product Name: ELA-14 (human)
CAS No.: 1886973-05-2
Chemical Name: ELA-14 (human)
Synonyms: Elabela(19-32);ELA-14 (human);Glp-RRCMPLHSRVPFP;ELA-14 (human) TFA;Elabela(19-32)、ELA-14 (human);L-Proline, 5-oxo-L-prolyl-L-arginyl-L-arginyl-L-cysteinyl-L-methionyl-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl-
CBNumber: CB74902716
Molecular Formula: C75H119N25O17S2
Formula Weight: 1707.03
MOL File: 1886973-05-2.mol

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ELA-14 (human) Property

form: Solid
color: White to off-white
Sequence: {Glp}-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6293
Product name: ELA-14(human)
Packaging: 1
Price: $193
Updated: 2021/12/16

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ELA-14 (human) Chemical Properties,Usage,Production

Uses

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].

in vivo

Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t_1/2<2 min)^[1].

References

[1] Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72. DOI:10.1021/acs.jmedchem.5b01549

ELA-14 (human) Preparation Products And Raw materials

Raw materials

Preparation Products

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ELA-14 (human) Suppliers

China 26 United Kingdom 1 United States 2 Global 29

Beijing Solarbio Science & Tecnology Co., Ltd.

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1886973-05-2, ELA-14 (human)Related Search:

H-LEU-PRO-ARG-LEU-LEU-HIS-THR-ASP-SER-ARG-MET-ALA-THR-ILE-ASP-PHE-PRO-LYS-LYS-ASP-PRO-THR-THR-SER-LEU-GLY-ARG-PRO-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 [NPHE1]NOCICEPTIN(1-13)NH2 Cenupatide Met-enkephalinamide GLY-SER-SER-PHE-LEU-SER-PRO-GLU-HIS-GLN-LYS-ALA-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG RRKDLHDDEEDEAMSITA GIP (HUMAN) ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN

ELA-14 (human)

L-Proline, 5-oxo-L-prolyl-L-arginyl-L-arginyl-L-cysteinyl-L-methionyl-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl-

Elabela(19-32)

Glp-RRCMPLHSRVPFP

ELA-14 (human) TFA

Elabela(19-32)、ELA-14 (human)

1886973-05-2

C75H119N25O17S2