GIP (HUMAN)

Product Name: GIP (HUMAN)
CAS No.: 100040-31-1
Chemical Name: GIP (HUMAN)
Synonyms: GIP;GIP (HUMAN);GIP (Total);GIP (active);M.W. 4983.59 C226H338N60O66S;GASTRIC INHIBITORY PEPTIDE HUMAN;GASTRIC INHIBITORY POLYPEPTIDE (HUMAN);YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ;Gastric inhibitorypolypeptide (human) (9CI);Gastric inhibitory polypeptide human, ≥95% (HPLC)
CBNumber: CB3381115
Molecular Formula: C226H338N60O66S
Formula Weight: 4983.52932
MOL File: 100040-31-1.mol

More

Less

GIP (HUMAN) Property

storage temp.: −20°C
form: Solid
Water Solubility: Soluble to 1 mg/ml in water
Sequence: H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G2269
Product name: Gastric Inhibitory Polypeptide human
Purity: ≥95% (HPLC)
Packaging: 0.1mg
Price: $404
Updated: 2024/03/01

Sigma-Aldrich

Product number: G2269
Product name: Gastric Inhibitory Polypeptide human
Purity: ≥95% (HPLC)
Packaging: 0.5mg
Price: $1620
Updated: 2024/03/01

Sigma-Aldrich

Product number: G2269
Product name: Gastric Inhibitory Polypeptide human
Purity: ≥95% (HPLC)
Packaging: .1mg
Price: $358
Updated: 2022/05/15

Sigma-Aldrich

Product number: G2269
Product name: Gastric Inhibitory Polypeptide human
Purity: ≥95% (HPLC)
Packaging: .5mg
Price: $1440
Updated: 2022/05/15

Alfa Aesar

Product number: J66667
Product name: Gastric Inhibitory Peptide, human
Packaging: 0.5mg
Price: $135
Updated: 2021/12/16

More

Less

GIP (HUMAN) Chemical Properties,Usage,Production

Description

GIP was originally isolated as a gastric inhibitory polypeptide. After the discovery of its glucose-dependent insulinotropic activity, known as the incretin effect, GIP was renamed glucose-dependent insulinotropic peptide.
Gastric inhibitory peptide
Abbreviation: GIP
Additional names: gastric inhibitory polypeptide,gastrointestinal inhibitory peptide, glucose-dependent, insulinotropic peptide

Chemical Properties

Human GIP: Mr 4983.6, theoretical pI 6.92. GIP is soluble in water, but insoluble in ethanol. GIP is inactivated by DPP-4.

History

GIP was originally isolated from the porcine intestinal extract on the basis of its acid inhibitory activity in dogs (gastric inhibitory polypeptide) in the early 1970s, and subsequently renamed glucose-dependent insulinotropic peptide after the finding of its physiologically important role as a potentiator of glucose-stimulated insulin secretion.

Uses

GIP possessing incretin activity enhances glucosestimulated insulin release. GIP agonists are potentially useful for the treatment of diabetes. Moreover, DPP-4 inhibitors are approved for use in diabetes patients because GIP is rapidly deactivated by DPP-4.

Biosynthesis

The expression of GIP is regulated by nutrients. The administration of glucose and lipid into the rat gastrointestinal tract increases GIP mRNA levels. Circulating GIP levels are low in the fasted state and increase within minutes of food ingestion. The postprandial levels of circulating GIP are dependent on meal size. The degree to which nutrients regulate GIP secretion is speciesdependent. Fat is a more potent stimulator than carbohydrates in humans, whereas in the rodent and pig, carbohydrates are more potent than fat. Once released, GIP is rapidly deactivated by DPP-4.

Receptors

Structure and subtype
The receptor of GIP is a seven-transmembrane GPCR that belongs to a subclass of the family B. Both the relatively long extracellular N-terminal domain and the first transmembrane domain are important for ligand binding and receptor activation. The C-terminal cytoplasmic domain of the receptor is important for receptor desensitization and internalization. Like their peptide ligands, the GIP receptor and the GLP-1 receptor exhibit high degrees of amino acid sequence identity, with similar molecular structures and signaling processes. However, GIP does not bind to the GLP-1 receptor and vice versa.
Signal transduction pathway
Ligand binding to the GIP receptor primarily activates adenylyl cyclase and increases intracellular cAMP.6 The activation of the MAP kinase pathway, the phospholipase A2 pathway, and the phosphatidylinositol 3-kinase/protein kinase B pathway have also been reported.
Agonist
[D-Ala2]-GIP is an agonist. Tirzepatide (LY3298176) is a dual agonist of GIP and GLP-1 receptors.
Antagonists
GIP(6–30), ANTGIP (GIP-(7–30)-NH2) (a truncated GIP peptide antagonist), GIP(3–30)NH2 (a truncated GIP peptide antagonist), and [Pro3]-GIP; Exendin(9–39) amide are antagonists.

storage

Store at -20°C

Structure and conformation

Human GIP is a single 42-aa peptide. The structure of vertebrate GIP is well conserved and both the N-terminal and central regions are important for biological activity because truncated forms of GIP, GIP(1–39), and GIP (1–30) show a high degree of biological activity.2 The N-terminal two aa residues are cleaved off by dipeptidyl-peptidase 4 (DPP-4) in the circulation to form GIP(3–42), which has no insulinotropic activity.

GIP (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GIP (HUMAN) Suppliers

China 81 Europe 1 Germany 3 Japan 1 Switzerland 1 United Kingdom 1 United States 17 USA 1 Global 106

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alabiochem Tech.Co., Ltd.

Tel: 0512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 996
Advantage: 59

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1011
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13359
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Watson Biotechnology Co.,Ltd

Tel: 027-027-59207879 18140587686
Fax: QQ：1972026995
Email: kf@3600chem.com
Country: China
ProdList: 4697
Advantage: 55

More

Less

View Lastest Price from GIP (HUMAN) manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: GIP (HUMAN) 100040-31-1
Price: US $0.00/MG
Min. Order: 1MG
Purity: 98%
Supply Ability: 20 TONS
Release date: 2023-07-27

Career Henan Chemical Co

Product: GIP (HUMAN) 100040-31-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

100040-31-1, GIP (HUMAN)Related Search:

PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE COBALT(II) ACETYLACETONATE Tosylmethyl isocyanide Cupric acetylacetonate Ethyl isocyanoacetate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate Ferric acetylacetonate TERT-BUTYL ISOCYANIDE SALCOMINE Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) GIP （Gastric Inhibitory polypeptide）

H-TYR-ALA-GLU-GLY-THR-PHE-ILE-SER-ASP-TYR-SER-ILE-ALA-MET-ASP-LYS-ILE-HIS-GLN-GLN-ASP-PHE-VAL-ASN-TRP-LEU-LEU-ALA-GLN-LYS-GLY-LYS-LYS-ASN-ASP-TRP-LYS-HIS-ASN-ILE-THR-GLN-OH

GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (HUMAN)

GASTRIC INHIBITORY PEPTIDE HUMAN

GASTRIC INHIBITORY POLYPEPTIDE (HUMAN)

GIP (HUMAN)

GIP

YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ

TYR-ALA-GLU-GLY-THR-PHE-ILE-SER-ASP-TYR-SER-ILE-ALA-MET-ASP-LYS-ILE-HIS-GLN-GLN-ASP-PHE-VAL-ASN-TRP-LEU-LEU-ALA-GLN-LYS-GLY-LYS-LYS-ASN-ASP-TRP-LYS-HIS-ASN-ILE-THR-GLN

Gastric Inhibitory Polypeptide (huMan) GIP (huMan), Glucose-Dependent Insulinotropic Polypeptide (huMan)

GIP (huMan), Glucose-Dependent Insulinotropic Polypeptide (huMan)

GIP, Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln

M.W. 4983.59 C226H338N60O66S

REF DUPL: H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH

Gastric inhibitorypolypeptide (human) (9CI)

Gastric Inhibitory Polypeptide huManGastric Inhibitory Polypepti

Gastric inhibitory polypeptide human, ≥95% (HPLC)

GIP (active)

GIP (Total)

100040-31-1

C226H338N60O66S

Gastrointestinal Products

Gastric Inhibitory Polypeptides

Peptides

Biochemicals and Reagents

BioChemical

Amino Acids and Peptides

peptide

Glucagon receptor and related