ChemicalBook > CAS DataBase List > 4-(2-Aminoethyl)benzenesulfonamide

4-(2-Aminoethyl)benzenesulfonamide

Uses

Product Name: 4-(2-Aminoethyl)benzenesulfonamide
CAS No.: 35303-76-5
Chemical Name: 4-(2-Aminoethyl)benzenesulfonamide
Synonyms: TIMTEC-BB SBB003544;OTAVA-BB BB7020410047;Glipizide Impurity 32;Glipizide Impurity 14;LABOTEST-BB LT00080735;Glimepiride Impurity 26;4-Aminoethylbenzenesulfonamide;P-Aminoethylbenzenesulfonamide;Glimepiride Sulfonamide Impurity;4-(2-Aminoethyl)benzesulfonamide
CBNumber: CB5480434
Molecular Formula: C8H12N2O2S
Formula Weight: 200.26
MOL File: 35303-76-5.mol

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4-(2-Aminoethyl)benzenesulfonamide Property

Melting point:: 150-152 °C (lit.)
Boiling point:: 387.4±44.0 °C(Predicted)
Density: 1.2581 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.5690 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.16±0.10(Predicted)
form: Solid
color: White
Water Solubility: 15.5g/L at 20℃
InChI: InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12)
InChIKey: FXNSVEQMUYPYJS-UHFFFAOYSA-N
SMILES: C1(S(N)(=O)=O)=CC=C(CCN)C=C1
LogP: -3.1 at 19.8℃
CAS DataBase Reference: 35303-76-5(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi,Xn
Risk Statements: 34-22-36/37/38-20/21/22
Safety Statements: 45-36/37/39-26-36-24/25
RIDADR: UN3259
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
PackingGroup: III
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H290May be corrosive to metals

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 275247
Product name: 4-(2-Aminoethyl)benzenesulfonamide
Purity: 99%
Packaging: 25g
Price: $96.9
Updated: 2025/07/31

TCI Chemical

Product number: A1363
Product name: 4-(2-Aminoethyl)benzenesulfonamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $61
Updated: 2025/07/31

TRC

Product number: A608790
Product name: 4-(2-Aminoethyl)benzenesulfonamide
Packaging: 10g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: J91166
Product name: 4-(2-Aminoethyl)benzenesulfonamide
Packaging: 25g
Price: $25
Updated: 2021/12/16

Apolloscientific

Product number: OR9989
Product name: 4-(2-Aminoethyl)benzenesulphonamide
Packaging: 25g
Price: $28
Updated: 2021/12/16

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4-(2-Aminoethyl)benzenesulfonamide Chemical Properties,Usage,Production

Uses

4-(2-Aminoethyl)benzenesulfonamide is used as the starting material in the synthesis of Des(5-methylpyrazinecarbonyl) trans-4-Methyl Glipizide (D292605); a degradation product of Glimepiride (G410150) which is a sulfonylurea hypoglycemic agent and an antidiabetic. 4-(2-Aminoethyl)benzenesulfonamide is also used as a reagent in the synthesis of deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.

Chemical Properties

white to yellowish crystalline powder

Uses

4-(2-Aminoethyl)benzenesulfonamide was used to develop a model system to study the implementation of a microfluid chip required for Fourier transform measurements of biochemical interactions.

General Description

The human hepatocellular carcinoma (HCC) cells were treated with its inhibitor 4-(2-aminoethyl)benzenesulfonamide.

Flammability and Explosibility

Not classified

Synthesis

223253-87-0

35303-76-5

The general procedure for the synthesis of 4-(2-aminoethyl)benzenesulfonamide from the compound (CAS:223253-87-0) was as follows: compound II was dissolved in 80 mL of acetone. Under the condition of ice water bath, 150 mL of concentrated ammonia was added to the reaction mixture and the reaction was stirred at room temperature. After completion of the reaction, the mixture was poured into 500 mL of ice water and the solid was collected by filtration. The filter cake was acidified with 200 mL of 2N hydrochloric acid. Subsequently, the mixture was heated to reflux for 6 hours and filtered. The filtrate was dissolved in hot water and the pH was adjusted to 11-12 with 2N KOH solution. after cooling in an ice bath, the solution was boiled naturally and cooled again to precipitate a pale yellow precipitate. After filtration, it was dried under vacuum to obtain 21.6 g (0.108 mol) of compound III, i.e., 4-(2-aminoethyl)benzenesulfonamide.

References

[1] Patent: CN107879955, 2018, A. Location in patent: Paragraph 0050

4-(2-Aminoethyl)benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-Aminoethyl)benzenesulfonamide Suppliers

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View Lastest Price from 4-(2-Aminoethyl)benzenesulfonamide manufacturers

Guangzhou Tosun Pharmaceutical Ltd

Product: Glipizide Impurity 4 35303-76-5
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2025-02-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(2-Aminoethyl)benzene sulfonamide 35303-76-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(2-Aminoethyl)benzene sulfonamide 35303-76-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

35303-76-5, 4-(2-Aminoethyl)benzenesulfonamideRelated Search:

Phenethyl isocyanate 3-Ethyl-2,5-Dihydro-4-Methyl-2-Oxo-N-(2-Phenylethyl)-1h-Pyrrole-1-Carboxamide GLIMEPIRIDE RELATED COMPOUND C (20 MG) (GLIMEPIRIDE URETHANE) 4-12-00-02470 (Beilstein Handbook Reference) Glimepiride Impurity 19 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide trans-4-Methylcyclohexyl amine methyl hydrogen sulphate Glimepiride Impurity 2 Meta-GliMepiride IMpurity GliMepiride EP IMpurity J Benzenesulfonamide, 3-(2-aminoethyl)- (9CI) trans-4-Methycyclohexyl isocyanate ortho-GliMepiride IMpurity [[4-[2-[[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]-carbamic acid ethyl ester cis-Glimepiride Glimepiride Glimepiride Impurity 30

Glimepiride Sulfonamide Impurity

Glipizide Impurity 32

Glimepiride Impurity 26

Glipizide Impurity 14

P-(2-AMINOETHYL)BENZENESULFONAMIDE

OTAVA-BB BB7020410047

TIMTEC-BB SBB003544

LABOTEST-BB LT00080735

4-(2-AMINOETHYL)BENZENESULFONAMIDE

4-(2-AMINOETHYL)BENZENE SULFONMIDE

4-(2-AMINOETHYL)BENZENE SULPHONAMIDE

4-(2-Ethylamino) Benzene Sulfonamide

4-Aminoethylbenzenesulfonamide

Benzenesulfonamide, 4-(2-aminoethyl)- (9CI)

4-(2-Aminoethyl)benzesulfonamide

4-(2-aminoethyl)benzenesulfonamide (intermediate of glibenclamide,glipizide,gliquidone)

Benzenesulfonamide, 4-(2-aminoethyl)-

4-(2-Aminoethyl)benzenesulfonamide,99%

4-(2-AMinoethyl)benzenesulfonaMide, 99% 25GR

2-AMino Ethyl Benzene SulfonaMide

4-(2-AMinoethyl)benzene sulfonaMide 3,11-dichloro-6,11-dihydro-6-Methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

4-(2-Aminoethyl)benzenesulfonamide 99%

4-(2-Amino Ethyl) Benzene Sulfonamide (Glipizide Intermediate) (35303-76-5)

4-(2-Aminoethyl)benzolsulfonamid

4-(2-Aminoethyl)benzenesulfonamide &gt

4-(2-Aminoethyl)benzenesulfonamide ISO 9001：2015 REACH

Glipizide Impurity 3（4-(2-Aminoethyl)benzenesulfonamide）

4-(2-aminoethyl)-benzenesufonamide [AEBS]

4-(2-aminoethyl)-benzenesufonamide

P-Aminoethylbenzenesulfonamide

35303-76-5

25303-76-5

C8H12N1O2S1

H2NCH2CH2C6H4SO2NH2

Building Blocks

Organic Building Blocks

Sulfonamides/Sulfinamides

Sulfur Compounds

SULFONAMIDE

Benzene derivates

(intermediate of glibenclamide,glipizide,gliquido

Organic Building Blocks

Sulfonamides/Sulfinamides

Sulfur Compounds