ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE

Product Name: ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
CAS No.: 123770-62-7
Chemical Name: ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
Synonyms: ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE;ethyl 5-(hydroxymethyl)-1,2-oxazole-3-carboxylate;5-(hydroxymethyl)-3-isoxazolecarboxylic acid ethyl ester;5-(Hydroxymethyl)isoxazole-3-carboxylic acid ethyl ester;3-Isoxazolecarboxylic acid, 5-(hydroxymethyl)-, ethyl ester
CBNumber: CB5485136
Molecular Formula: C7H9NO4
Formula Weight: 171.15
MOL File: 123770-62-7.mol

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ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Property

Boiling point:: 338.8±32.0 °C(Predicted)
Density: 1.280±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.12±0.10(Predicted)
Appearance: Light yellow to yellow Liquid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B433630
Product name: Ethyl5-(Hydroxymethyl)isoxazole-3-carboxylate
Packaging: 500mg
Price: $310
Updated: 2021/12/16

Matrix Scientific

Product number: 125927
Product name: Ethyl5-(hydroxymethyl)isoxazole-3-carboxylate
Purity: >95%
Packaging: 500mg
Price: $122
Updated: 2021/12/16

Matrix Scientific

Product number: 125927
Product name: Ethyl5-(hydroxymethyl)isoxazole-3-carboxylate
Purity: >95%
Packaging: 1g
Price: $164
Updated: 2021/12/16

Matrix Scientific

Product number: 125927
Product name: Ethyl5-(hydroxymethyl)isoxazole-3-carboxylate
Purity: >95%
Packaging: 5g
Price: $654
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077610
Product name: ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $753.12
Updated: 2021/12/16

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ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

626-35-7

107-19-7

123770-62-7

The general procedure for the synthesis of ethyl 5-hydroxymethylisoxazole-3-carboxylate from ethyl nitroacetate and 2-propyn-1-ol was as follows: intermediate 4- Preparation of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate. In an Ace pressure tube, 2-propyn-1-ol (1.0 mL, 16.76 mmol) and ethyl nitroacetate (3.79 mL, 33.52 mmol) were dissolved in ethanol (23.5 mL), followed by the addition of 1,4-diazabicyclo[2.2.2]octane (DABCO, 0.194 g, 1.68 mmol). The reaction tube was sealed and the reaction was heated at 80 °C for 72 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure. The resulting residue was purified by fast column chromatography on silica gel, the eluent being a mixture of dichloromethane and methanol (methanol v/v fraction 0% to 6%), resulting in ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 2.32 g in 81% yield as an oil.ESI/APCI (+): m/z 172 ([M+H]+).

References

[1] European Journal of Organic Chemistry, 2007, # 26, p. 4352 - 4359
[2] Journal of the American Chemical Society, 2014, vol. 136, # 48, p. 16792 - 16799
[3] Patent: WO2010/142801, 2010, A1. Location in patent: Page/Page column 147
[4] Chemistry - A European Journal, 2012, vol. 18, # 7, p. 2081 - 2093
[5] European Journal of Organic Chemistry, 2016, vol. 2016, # 27, p. 4643 - 4655

ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Suppliers

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123770-62-7, ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATERelated Search:

ETHYL 5-(1-HYDROXY-1,5-DIMETHYLHEX-4-EN-1-YL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-HYDROXYCYCLOPENTYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-CYCLOPROPYL-1-HYDROXYETHYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-HYDROXYCYCLOHEXYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-[5-ACETYL-3-(BENZOYLAMINO)-2-OXO-2H-PYRAN-6-YL]-3-ISOXAZOLECARBOXYLATE ETHYL 5-(1-HYDROXY-1-METHYLETHYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-HYDROXY-1-METHYLBUTYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE

ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE

5-(Hydroxymethyl)isoxazole-3-carboxylic acid ethyl ester

5-(hydroxymethyl)-3-isoxazolecarboxylic acid ethyl ester

3-Isoxazolecarboxylic acid, 5-(hydroxymethyl)-, ethyl ester

ethyl 5-(hydroxymethyl)-1,2-oxazole-3-carboxylate

123770-62-7