ChemicalBook > CAS DataBase List > ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE

ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE

Product Name
ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
CAS No.
123770-62-7
Chemical Name
ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
Synonyms
ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE;ethyl 5-(hydroxymethyl)-1,2-oxazole-3-carboxylate;5-(hydroxymethyl)-3-isoxazolecarboxylic acid ethyl ester;5-(Hydroxymethyl)isoxazole-3-carboxylic acid ethyl ester;3-Isoxazolecarboxylic acid, 5-(hydroxymethyl)-, ethyl ester
CBNumber
CB5485136
Molecular Formula
C7H9NO4
Formula Weight
171.15
MOL File
123770-62-7.mol
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ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Property

Boiling point:
338.8±32.0 °C(Predicted)
Density 
1.280±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
13.12±0.10(Predicted)
Appearance
Light yellow to yellow Liquid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B433630
Product name
Ethyl5-(Hydroxymethyl)isoxazole-3-carboxylate
Packaging
500mg
Price
$310
Updated
2021/12/16
Matrix Scientific
Product number
125927
Product name
Ethyl5-(hydroxymethyl)isoxazole-3-carboxylate
Purity
>95%
Packaging
500mg
Price
$122
Updated
2021/12/16
Matrix Scientific
Product number
125927
Product name
Ethyl5-(hydroxymethyl)isoxazole-3-carboxylate
Purity
>95%
Packaging
5g
Price
$654
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077610
Product name
ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$753.12
Updated
2021/12/16
Matrix Scientific
Product number
125927
Product name
Ethyl5-(hydroxymethyl)isoxazole-3-carboxylate
Purity
>95%
Packaging
1g
Price
$164
Updated
2021/12/16
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ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

626-35-7

107-19-7

123770-62-7

The general procedure for the synthesis of ethyl 5-hydroxymethylisoxazole-3-carboxylate from ethyl nitroacetate and 2-propyn-1-ol was as follows: intermediate 4- Preparation of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate. In an Ace pressure tube, 2-propyn-1-ol (1.0 mL, 16.76 mmol) and ethyl nitroacetate (3.79 mL, 33.52 mmol) were dissolved in ethanol (23.5 mL), followed by the addition of 1,4-diazabicyclo[2.2.2]octane (DABCO, 0.194 g, 1.68 mmol). The reaction tube was sealed and the reaction was heated at 80 °C for 72 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure. The resulting residue was purified by fast column chromatography on silica gel, the eluent being a mixture of dichloromethane and methanol (methanol v/v fraction 0% to 6%), resulting in ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 2.32 g in 81% yield as an oil.ESI/APCI (+): m/z 172 ([M+H]+).

References

[1] European Journal of Organic Chemistry, 2007, # 26, p. 4352 - 4359
[2] Journal of the American Chemical Society, 2014, vol. 136, # 48, p. 16792 - 16799
[3] Patent: WO2010/142801, 2010, A1. Location in patent: Page/Page column 147
[4] Chemistry - A European Journal, 2012, vol. 18, # 7, p. 2081 - 2093
[5] European Journal of Organic Chemistry, 2016, vol. 2016, # 27, p. 4643 - 4655

ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE Suppliers

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123770-62-7, ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATERelated Search:

ETHYL 5-(1-HYDROXY-1,5-DIMETHYLHEX-4-EN-1-YL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-HYDROXYCYCLOPENTYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-CYCLOPROPYL-1-HYDROXYETHYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-HYDROXYCYCLOHEXYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-[5-ACETYL-3-(BENZOYLAMINO)-2-OXO-2H-PYRAN-6-YL]-3-ISOXAZOLECARBOXYLATE ETHYL 5-(1-HYDROXY-1-METHYLETHYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(1-HYDROXY-1-METHYLBUTYL)ISOXAZOLE-3-CARBOXYLATE ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE

  • ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE
  • 5-(Hydroxymethyl)isoxazole-3-carboxylic acid ethyl ester
  • 5-(hydroxymethyl)-3-isoxazolecarboxylic acid ethyl ester
  • 3-Isoxazolecarboxylic acid, 5-(hydroxymethyl)-, ethyl ester
  • ethyl 5-(hydroxymethyl)-1,2-oxazole-3-carboxylate
  • 123770-62-7