Boc-L-aspartic acid 4-tert-butyl ester

Product Name: Boc-L-aspartic acid 4-tert-butyl ester
CAS No.: 1676-90-0
Chemical Name: Boc-L-aspartic acid 4-tert-butyl ester
Synonyms: BOC-ASP(OTBU)-OH;BOC-L-ASP(TBU)-OH;BOC-ASP(OBUT)-OH;BOC-L-ASP(OTBU)-OH;L-BOC-ASP(OTBU)-OH;Boc-L-Asp(OtBu)-0H;Boc-L-Asp(Otbu)-OH >98%;BOC-ASPARTIC ACID(OTBU)-OH;4-tert-Butyl N-Boc-L-aspartate;(Tert-Butoxy)Carbonyl Asp(OtBu)-OH
CBNumber: CB5485550
Molecular Formula: C13H23NO6
Formula Weight: 289.32
MOL File: 1676-90-0.mol

More

Less

Boc-L-aspartic acid 4-tert-butyl ester Property

Melting point:: 64-67 °C
alpha: 2 º (c=1% in MeOH)
Boiling point:: 432.6±40.0 °C(Predicted)
Density: 1.139±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in methanol and dimethyl sulfoxide.
form: Powder
pka: 3.69±0.23(Predicted)
color: White
optical activity: [α]20/D +2.0±0.4°, c = 1% in methanol
BRN: 2336144
InChI: InChI=1S/C13H23NO6/c1-12(2,3)19-9(15)7-8(10(16)17)14-11(18)20-13(4,5)6/h8H,7H2,1-6H3,(H,14,18)(H,16,17)/t8-/m0/s1
InChIKey: PHJDCONJXLIIPW-QMMMGPOBSA-N
SMILES: C(O)(=O)[C@H](CC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 1676-90-0(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29241990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15429
Product name: Boc-Asp(OtBu)-OH
Purity: ≥99.0% (sum of enantiomers, TLC)
Packaging: 1g
Price: $93.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15429
Product name: Boc-Asp(OtBu)-OH
Purity: ≥99.0% (sum of enantiomers, TLC)
Packaging: 5G
Price: $389.9
Updated: 2025/07/31

TCI Chemical

Product number: B3935
Product name: 4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B3935
Product name: 4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $126
Updated: 2025/07/31

TRC

Product number: B809200
Product name: N-tert-Butyloxycarbonyl-L-asparticAcidβ-tert-ButylEster
Packaging: 1g
Price: $65
Updated: 2021/12/16

More

Less

Boc-L-aspartic acid 4-tert-butyl ester Chemical Properties,Usage,Production

Uses

It is used in the preparation of highly selective thrombin inhibitors. Also used in the preparation of thiopeptides and thioacylating agents.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

3057-74-7

1676-90-0

2.1. Preparation of Boc-Asp(O-tBu)-NCA (II-a) The method involves the main chain cyclization of a free carboxylic acid in which the amine functional group is protected by Boc. First, (Boc)2-Asp(Ot-Bu)-OH (VII-a) needs to be prepared. The specific steps are as follows: 1. esterify the α-carboxylic acid of Boc-Asp(Ot-Bu)-OH (Va) to benzyl ester (VI-a). 2. reaction with Boc2O in the presence of DMAP to give the bis-Boc-protected amino compound (VII-a). 3. removal of the benzyl ester protecting group by hydrogenation to give (VIII-a). Subsequent steps include cyclization with Vilsmeier salt protected amino acid (VIII-a). The optimum reaction conditions were in acetonitrile with the salt formed from DMF and oxalyl chloride. The final compound (II-a) was obtained in 90% yield.

References

[1] Patent: US2010/16631, 2010, A1. Location in patent: Page/Page column 5-6
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 15, p. 4975 - 4978
[3] Patent: WO2017/24009, 2017, A1. Location in patent: Paragraph 0652
[4] Russian Journal of Bioorganic Chemistry, 1999, vol. 25, # 5, p. 283 - 287
[5] Bioorganicheskaya Khimiya, 1999, vol. 25, # 5, p. 323 - 328

Boc-L-aspartic acid 4-tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Boc-L-aspartic acid 4-tert-butyl ester Suppliers

Americas 1 China 210 Europe 1 France 1 Germany 6 India 6 Japan 3 South Korea 1 Switzerland 3 United Kingdom 8 United States 29 Global 269

Shanghai Jifeng Biotechnology Co., Ltd.

Tel: 021-61263377 15023907684
Fax: 021-61263399
Email: 15800684150@163.com
Country: China
ProdList: 8131
Advantage: 58

Nanjing Yuye Biotechnology Co., Ltd.

Tel: 17826523762
Email: 3437309915@qq.com
Country: China
ProdList: 81
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

More

Less

View Lastest Price from Boc-L-aspartic acid 4-tert-butyl ester manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-Asp(OtBu)-OH 1676-90-0
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-10-15

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Asp(Otbu)-OH 1676-90-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-22

Honest Joy Holdings Limited

Product: Boc-Asp(otBu)-OH 1676-90-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-02-08

1676-90-0, Boc-L-aspartic acid 4-tert-butyl esterRelated Search:

BUTYL OLEATE Cyhalofop-butyl N-Boc-L-valine tert-Butanol Tris(trimethylsilyl)phosphate tert-Butyl peroxyacetate Diethylene glycol monobutyl ether Buprofezin Boc-Aib-OH Poly-L-aspartic acid Fmoc-Lys(Boc)-OH L-ASPARTIC ACID Butyl acetate BOC-GLY-LEU-OH BOC-D-2-PYRIDYLALANINE N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-L-glutamic acid 5-cyclohexyl ester BOC-ORN-OH

4-[(2-methylpropan-2-yl)oxy]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-oxobutanoic acid

N-Boc-L-aspartic acid 4-tert-butyl ester, 98%

N-tert-Butyloxycarbonyl-L-aspartic Acid β-tert-Butyl Ester

BOC-L-ASP(OTBU)-OH

BOC-L-ASP(TBU)-OH

BOC-L-ASPARTIC ACID-BETA-T-BUTYL ESTER

BOC-L-ASPARTIC ACID 4-TERT-BUTYL ESTER

BOC-ASP(OBUT)-OH

BOC-ASPARTIC ACID(OTBU)-OH

BOC-ASP(OTBU)-OH

Boc-L-aspartic acid ?-tert-butyl ester99%

4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate

N-(tert-Butoxycarbonyl)-L-aspartic Acid 4-tert-Butyl Ester 4-tert-Butyl N-Boc-L-aspartate N-Boc-L-aspartic Acid 4-tert-Butyl Ester Boc-Asp(OtBu)-OH

(2S)-4-tert-butoxy-2-[(tert-butoxycarbonyl)aMino]-4-oxobutanoic acid

N-ALPHA-T-BOC-L-ASPARTIC ACID BETA-T-BUTYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID-BETA-T-BUTYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID-4-T-BUTYL ESTER

N-ALPHA-T-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-T-BUTYL ESTER

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER

(S)-4-tert-butoxy-2-(tert-butoxycarbonylamino)-4-oxobutanoic acid

Boc-L-aspartic acid-beta-tert-butyl ester

L-BOC-ASP(OTBU)-OH

(Tert-Butoxy)Carbonyl Asp(OtBu)-OH

4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate &gt

tert-Butyloxycarbonyl-L-aspartic acid 4-tert-butyl ester

L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester

4-tert-Butyl N-Boc-L-aspartate

BOC-L-ASPARTIC ACID 4-TERT-BUTYL ESTER 1676-90-0

Boc-L-aspartic acid 4-tert-butyl ester USP/EP/BP

Boc-L-aspartic acid β-tert-butyl ester

Tert-butoxycarbonyl -L- aspartic acid -4- tert-butyl ester

Tert butoxycarbonyl L-aspartate 4-tert butyl ester

Boc-L-aspartate 4-tert-butyl ester

Boc-L-Asp(OtBu)-0H

Boc-L-Asp(Otbu)-OH >98%

1676-90-0

CH33COCOCH2CHCOOHNHCOOCCH33

Specialty Synthesis

Peptide Synthesis

Amino Acid Derivatives

Aspartic Acid

Aspartic acid [Asp, D]

Boc-Amino Acids and Derivative

Boc-Amino acid series