HC≡C-CH2-PEG3-SH

Product Name: HC≡C-CH2-PEG3-SH
CAS No.: 1412905-18-0
Chemical Name: HC≡C-CH2-PEG3-SH
Synonyms: HC≡C-CH2-PEG3-SH;Propargyl-PEG3-SH;Ethanethiol, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-;2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethane-1-thiol
CBNumber: CB54868344
Molecular Formula: C9H16O3S
Formula Weight: 204.29
MOL File: 1412905-18-0.mol

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HC≡C-CH2-PEG3-SH Property

Boiling point:: 286.2±30.0 °C(Predicted)
Density: 1.053±0.06 g/cm3(Predicted)
pka: 9?+-.0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

purepeg

Product number: 437903
Product name: HS-PEG3-Propyne
Purity: min.95%
Packaging: 250mg
Price: $127
Updated: 2021/12/16

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HC≡C-CH2-PEG3-SH Chemical Properties,Usage,Production

Uses

Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HC≡C-CH2-PEG3-SH Preparation Products And Raw materials

Raw materials

Preparation Products

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HC≡C-CH2-PEG3-SH Suppliers

China 12 United States 2 Global 14

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1412905-18-0, HC≡C-CH2-PEG3-SHRelated Search:

2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL propargyl-PEG3-Acid

HC≡C-CH2-PEG3-SH

Propargyl-PEG3-SH

Ethanethiol, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-

2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethane-1-thiol

1412905-18-0