HC≡C-CH2-PEG6-SH

Product Name: HC≡C-CH2-PEG6-SH
CAS No.: 1422540-91-7
Chemical Name: HC≡C-CH2-PEG6-SH
Synonyms: HC≡C-CH2-PEG6-SH;Propargyl-PEG6-SH;3,6,9,12,15,18-hexaoxahenicos-20-yne-1-thiol;3,6,9,12,15,18-Hexaoxaheneicos-20-yne-1-thiol
CBNumber: CB53309419
Molecular Formula: C15H28O6S
Formula Weight: 336.44
MOL File: 1422540-91-7.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

purepeg

Product number: 437906
Product name: HC≡C-CH2-PEG6-SH
Purity: min.95%
Packaging: 1g
Price: $444
Updated: 2021/12/16

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HC≡C-CH2-PEG6-SH Chemical Properties,Usage,Production

Uses

Propargyl-PEG6-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biological Activity

Propargyl-PEG6-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HC≡C-CH2-PEG6-SH Preparation Products And Raw materials

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1422540-91-7, HC≡C-CH2-PEG6-SHRelated Search:

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HC≡C-CH2-PEG6-SH

Propargyl-PEG6-SH

3,6,9,12,15,18-Hexaoxaheneicos-20-yne-1-thiol

3,6,9,12,15,18-hexaoxahenicos-20-yne-1-thiol

1422540-91-7

C15H28O6S

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