Propargyl-PEG1-SS-alcohol
- Product Name
- Propargyl-PEG1-SS-alcohol
- CAS No.
- 1391914-41-2
- Chemical Name
- Propargyl-PEG1-SS-alcohol
- Synonyms
- Propargyl-PEG1-SS-alcohol;Ethanol, 2-[[2-(2-propyn-1-yloxy)ethyl]dithio]-;2-((2-(Prop-2-yn-1-yloxy)ethyl)disulfaneyl)ethan-1-ol
- CBNumber
- CB53062613
- Molecular Formula
- C7H12O2S2
- Formula Weight
- 192.3
- MOL File
- 1391914-41-2.mol
N-Bromosuccinimide Price
- Product number
- P839565
- Product name
- Propargyl-PEG1-SS-alcohol
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BP-22670
- Product name
- Propargyl-PEG1-SS-alcohol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $430
- Updated
- 2021/12/16
- Product number
- BP-22670
- Product name
- Propargyl-PEG1-SS-alcohol
- Purity
- 98%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- BIPG1739
- Product name
- Propargyl-PEG1-SS-alcohol
- Packaging
- 250mg
- Price
- $837
- Updated
- 2021/12/16
- Product number
- BP-22670
- Product name
- Propargyl-PEG1-SS-alcohol
- Purity
- 98%
- Packaging
- 1g
- Price
- $1020
- Updated
- 2021/12/16
Propargyl-PEG1-SS-alcohol Chemical Properties,Usage,Production
Description
Propargyl-PEG1-SS-alcohol is a Click Chemistry-ready crosslinker containing a propargyl group, a hydroxyl group and a cleavable disulfide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Uses
Propargyl-PEG1-SS-alcohol is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Disulfide Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Propargyl-PEG1-SS-alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG1-SS-alcohol Suppliers
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- Country
- United States
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- Fax
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View Lastest Price from Propargyl-PEG1-SS-alcohol manufacturers
- Product
- Propargyl-PEG1-SS-alcohol 1391914-41-2
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-21