Propargyl-PEG1-SS-PEG1-PFP ester
- Product Name
- Propargyl-PEG1-SS-PEG1-PFP ester
- CAS No.
- 1817735-30-0
- Chemical Name
- Propargyl-PEG1-SS-PEG1-PFP ester
- Synonyms
- Propargyl-PEG1-SS-PEG1-PFP ester;Perfluorophenyl 3-[2-[[2-(Prop-2-yn-1-yloxy)ethyl]disulfanyl]ethoxy]propanoate;perfluorophenyl 3-(2-((2-(prop-2-yn-1-yloxy)ethyl)disulfaneyl)ethoxy)propanoate;Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
- CBNumber
- CB43363988
- Molecular Formula
- C16H15F5O4S2
- Formula Weight
- 430.41
- MOL File
- 1817735-30-0.mol
Propargyl-PEG1-SS-PEG1-PFP ester Property
- Boiling point:
- 477.0±45.0 °C(Predicted)
- Density
- 1.413±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Propargyl-PEG1-SS-PEG1-PFP ester Chemical Properties,Usage,Production
Description
Propargyl-PEG1-SS-PEG1-PFP ester is a Click Chemistry crosslinker. PFP ester is reactive with amine-bearing molecule. The propargyl groups can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages.
Uses
Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Disulfide Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Propargyl-PEG1-SS-PEG1-PFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG1-SS-PEG1-PFP ester manufacturers
- Product
- Propargyl-PEG1-SS-PEG1-PFP ester 1817735-30-0
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >95.00%
- Supply Ability
- 50mg
- Release date
- 2024-03-21