DSPE-PEG5-propargyl
- Product Name
- DSPE-PEG5-propargyl
- CAS No.
- 2112737-93-4
- Chemical Name
- DSPE-PEG5-propargyl
- Synonyms
- DSPE-PEG5-proparg;DSPE-PEG5-propargl;DSPE-PEG5-propargyl;Octadecanoic acid, (2R)-5-hydroxy-5-oxido-10-oxo-2-[(1-oxooctadecyl)oxy]-4,6,13,16,19,22,25-heptaoxa-9-aza-5-phosphaoctacos-27-yn-1-yl ester
- CBNumber
- CB03373615
- Molecular Formula
- C55H104NO14P
- Formula Weight
- 1034.39
- MOL File
- 2112737-93-4.mol
N-Bromosuccinimide Price
- Product number
- BP-23659
- Product name
- DSPE-PEG5-propargyl
- Purity
- 98%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
DSPE-PEG5-propargyl Chemical Properties,Usage,Production
Description
DSPE-PEG8-propargyl is a PEG linker with attached DSPE and propargyl groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The hydrophilic PEG linker increases the water solubility of the compound. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Uses
DSPE-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DSPE-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DSPE-PEG5-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DSPE-PEG5-propargyl manufacturers
- Product
- DSPE-PEG5-propargyl 2112737-93-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- DSPE-PEG5-propargyl 2112737-93-4
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-30