Propargyl-PEG4-S-PEG4-acid
- Product Name
- Propargyl-PEG4-S-PEG4-acid
- CAS No.
- 2055041-20-6
- Chemical Name
- Propargyl-PEG4-S-PEG4-acid
- Synonyms
- Propargyl-PEG4-S-PEG4-acid;4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid;3-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
- CBNumber
- CB33163110
- Molecular Formula
- C22H40O10S
- Formula Weight
- 496.61
- MOL File
- 2055041-20-6.mol
Propargyl-PEG4-S-PEG4-acid Property
- Boiling point:
- 591.5±50.0 °C(Predicted)
- Density
- 1.141±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23191
- Product name
- Propargyl-PEG4-S-PEG4-acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $1400
- Updated
- 2021/12/16
Propargyl-PEG4-S-PEG4-acid Chemical Properties,Usage,Production
Description
Propargyl-PEG4-S-PEG4-acid is a PEG linker containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Propargyl-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-S-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-S-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG4-S-PEG4-acid manufacturers
- Product
- Propargyl-PEG4-S-PEG4-acid 2055041-20-6
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28