Propargyl-PEG4-(CH2)3-acid
- Product Name
- Propargyl-PEG4-(CH2)3-acid
- CAS No.
- 1872433-74-3
- Chemical Name
- Propargyl-PEG4-(CH2)3-acid
- Synonyms
- Propargyl-PEG4-CH2-acid;5,8,11,14-Tetraoxaheptadec-16-ynoic acid;4,7,10,13-tetraoxaheptadec-1-yn-17-oic acid
- CBNumber
- CB43363993
- Molecular Formula
- C13H22O6
- Formula Weight
- 274.31
- MOL File
- 1872433-74-3.mol
Propargyl-PEG4-(CH2)3-acid Property
- Boiling point:
- 401.0±40.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- pka
- 4.63±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23117
- Product name
- Propargyl-PEG4-(CH2)3-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-23117
- Product name
- Propargyl-PEG4-(CH2)3-acid
- Purity
- 98%
- Packaging
- 500mg
- Price
- $780
- Updated
- 2021/12/16
Propargyl-PEG4-(CH2)3-acid Chemical Properties,Usage,Production
Description
Propargyl-PEG4-(CH2)3-CO2H is a linker containing a propargyl group at one end and a carboxylic acid at the other end. The carboxylic acid reacts with amine groups in the presence of activators (EDC or HATU). Under the catalyzation of copper, the propargyl group forms linkage with azide group of biomolecules.
Uses
Propargyl-PEG4-CH2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-(CH2)3-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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