Propargyl-PEG3-methyl ester

Product Name: Propargyl-PEG3-methyl ester
CAS No.: 2086689-09-8
Chemical Name: Propargyl-PEG3-methyl ester
Synonyms: Propargyl-PEG3-methyl ester;methyl 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate;Methyl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, methyl ester
CBNumber: CB93373759
Molecular Formula: C11H18O5
Formula Weight: 230.26
MOL File: 2086689-09-8.mol

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Propargyl-PEG3-methyl ester Property

Boiling point:: 298.4±25.0 °C(Predicted)
Density: 1.063±0.06 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23515
Product name: Propargyl-PEG3-methylester
Purity: 98%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

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Propargyl-PEG3-methyl ester Chemical Properties,Usage,Production

Description

Propargyl-PEG3-methyl ester is a propargyl linker with a methyl ester. The propargyl group reacts with azide-bearing compounds via copper catalyzed azide-alkyne Click Chemistry. Methyl ester can be hydrolyzed under strong basic condition.

Uses

Propargyl-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-methyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Propargyl-PEG3-methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG3-methyl ester Suppliers

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2086689-09-8, Propargyl-PEG3-methyl esterRelated Search:

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Propargyl-PEG3-methyl ester

Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, methyl ester

methyl 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate

Methyl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate

2086689-09-8