Propargyl-PEG3-methyl ester
- Product Name
- Propargyl-PEG3-methyl ester
- CAS No.
- 2086689-09-8
- Chemical Name
- Propargyl-PEG3-methyl ester
- Synonyms
- Propargyl-PEG3-methyl ester;methyl 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate;Methyl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, methyl ester
- CBNumber
- CB93373759
- Molecular Formula
- C11H18O5
- Formula Weight
- 230.26
- MOL File
- 2086689-09-8.mol
Propargyl-PEG3-methyl ester Property
- Boiling point:
- 298.4±25.0 °C(Predicted)
- Density
- 1.063±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23515
- Product name
- Propargyl-PEG3-methylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
Propargyl-PEG3-methyl ester Chemical Properties,Usage,Production
Description
Propargyl-PEG3-methyl ester is a propargyl linker with a methyl ester. The propargyl group reacts with azide-bearing compounds via copper catalyzed azide-alkyne Click Chemistry. Methyl ester can be hydrolyzed under strong basic condition.
Uses
Propargyl-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-methyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG3-methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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