Propargyl-PEG4-5-nitrophenyl carbonate
- Product Name
- Propargyl-PEG4-5-nitrophenyl carbonate
- CAS No.
- 1422540-81-5
- Chemical Name
- Propargyl-PEG4-5-nitrophenyl carbonate
- Synonyms
- Propargyl-PEG4-5-nitrophenyl carbonate;2,5,8,11,14-Pentaoxaheptadec-16-ynoic acid, 4-nitrophenyl ester
- CBNumber
- CB53163109
- Molecular Formula
- C18H23NO9
- Formula Weight
- 397.38
- MOL File
- 1422540-81-5.mol
N-Bromosuccinimide Price
- Product number
- BP-22989
- Product name
- Propargyl-PEG4-5-nitrophenylcarbonate
- Purity
- 95%
- Packaging
- 500mg
- Price
- $560
- Updated
- 2021/12/16
Propargyl-PEG4-5-nitrophenyl carbonate Chemical Properties,Usage,Production
Description
Propargyl-PEG4-5-nitrophenyl carbonate is heterobifunctional reagent with a propargyl group and nitrophenyl group. The propargyl group enales the formation of triazole linkage with azide compounds or biomolecules via copper catalyzed Click Chemistry. Nitrophenyl group is reactive towards the amino group of lysine by means of stable urethane linkages. The PEG units enhance the solubility of the molecule in aqueous media.
Uses
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-5-nitrophenyl carbonate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-5-nitrophenyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
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