Propargyl-PEG4-(CH2)3-methyl ester
- Product Name
- Propargyl-PEG4-(CH2)3-methyl ester
- CAS No.
- 1872433-63-0
- Chemical Name
- Propargyl-PEG4-(CH2)3-methyl ester
- Synonyms
- Propargyl-PEG4-CH2-methyl ester;Propargyl-PEG4-(CH2)3-methyl este;Propargyl-PEG4-(CH2)3-methyl ester;5,8,11,14-Tetraoxaheptadec-16-ynoic acid, methyl ester
- CBNumber
- CB23163108
- Molecular Formula
- C14H24O6
- Formula Weight
- 288.34
- MOL File
- 1872433-63-0.mol
Propargyl-PEG4-(CH2)3-methyl ester Property
- Boiling point:
- 354.3±37.0 °C(Predicted)
- Density
- 1.058±0.06 g/cm3(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23109
- Product name
- Propargyl-PEG4-(CH2)3-methylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- BP-23109
- Product name
- Propargyl-PEG4-(CH2)3-methylester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $580
- Updated
- 2021/12/16
Propargyl-PEG4-(CH2)3-methyl ester Chemical Properties,Usage,Production
Description
Propargyl-PEG4-(CH2)3-methyl ester consists of a propargyl group and a methyl ester. The propargyl group reacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions to form a stable triazole linkage. Under strong basic condition, methyl ester can be hydrolyzed.
Uses
Propargyl-PEG4-CH2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2-methyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-(CH2)3-methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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