Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
- Product Name
- Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
- CAS No.
- 2055024-43-4
- Chemical Name
- Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
- Synonyms
- Propargyl-PEG4-Sulfone-PEG4-Boc;Propargyl-PEG4-Sulfone-PEG4-t-butyl ester;4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid, 1,1-dimethylethyl ester, 16,16-dioxide
- CBNumber
- CB53163114
- Molecular Formula
- C26H48O12S
- Formula Weight
- 584.72
- MOL File
- 2055024-43-4.mol
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester Property
- Boiling point:
- 647.7±55.0 °C(Predicted)
- Density
- 1.131±0.06 g/cm3(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23230
- Product name
- Propargyl-PEG4-Sulfone-PEG4-t-butylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-23230
- Product name
- Propargyl-PEG4-Sulfone-PEG4-t-butylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $720
- Updated
- 2021/12/16
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester Chemical Properties,Usage,Production
Description
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester is a PEG linker containing a propargyl group and t-butyl protected carboxyl group acid. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. The protected acid can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG4-Sulfone-PEG4-t-butyl ester manufacturers
- Product
- Propargyl-PEG4-Sulfone-PEG4-t-butyl ester 2055024-43-4
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28